antibody

Goat anti-Cortactin / EMS1 Antibody

MBS420330

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-Cortactin / EMS1 Antibody

Cortactin/EMS1

EMS1; CORTACTIN; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); Cttn; oncogene EMS1; CTTN; FLJ34459; 1110020L01Rik; EMS1; CORTACTIN; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); Cttn; oncogene EMS1; CTTN; FLJ34459; 1110020L01Rik

src substrate cortactin isoform a; Src substrate cortactin; src substrate cortactin; amplaxin; 1110020L01Rik; oncogene EMS1; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); cortactin; Amplaxin; Oncogene EMS1

CTTN

CTTN; CTTN; EMS1; EMS1

SRC8_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Cow

550

WKASAGHAVSIA

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx. 80kDa band observed in Mouse and Rat Brain lysates (calculated MW of 61.6kDa according to Human NP_005222.2 and of 61.2kDa according to Mouse NP_031829.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Paradis et al, J Cell Sci. 2008 Jun 15;121(Pt 12):1965-72; PMID 18495841). Recommended concentration: 0.01-0.03ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: N Terminus. Immunogen: Peptide with sequence WKASAGHAVSIA-C, from the N Terminus of the protein sequence according to NP_005222.2; NP_612632.1. Corresponding Immunizing Peptide: Catalog #MBS426626

Important Note: This antibody is expected to recognize both reported isoforms (NP_005222.2; NP_612632.1).

20357552

NP_005222.2

NM_005231.3

57,467 Da

Bacterial Invasion Of Epithelial Cells Pathway 149807!!Bacterial Invasion Of Epithelial Cells Pathway 148661!!E-cadherin Signaling In The Nascent Adherens Junction Pathway 138005!!FGF Signaling Pathway 137989!!N-cadherin Signaling Events Pathway 137919!!Pathogenic Escherichia Coli Infection Pathway 83103!!Pathogenic Escherichia Coli Infection Pathway 672459!!Pathogenic Escherichia Coli Infection Pathway 516!!Proteoglycans In Cancer Pathway 782000!!Proteoglycans In Cancer Pathway 782054

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

0.1 mg

290 USD