antibody

Goat anti-MRP5 Antibody

MBS420328

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-MRP5 Antibody

MRP5

MRP5; DKFZp686C1782; ABCC5; ATP-binding cassette; sub-family C (CFTR/MRP); member 5; ABC33; EST277145; MOAT-C; MOATC; SMRP; pABC11; ATP-binding cassette; sub-family C; member 5; canalicular multispecific organic anion transporter C; MRP5; DKFZp686C1782; ABCC5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ABC33; EST277145; MOAT-C; MOATC; SMRP; pABC11; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C

multidrug resistance-associated protein 5 isoform 1; Multidrug resistance-associated protein 5; multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5; multi-specific organic anion transporter C; canalicular multispecific organic anion transporter C; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11

ABCC5

ABCC5; ABCC5; MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145; MRP5; MOAT-C

MRP5_HUMAN

Polyclonal

Goat

Human, Mouse, Rat. Dog, Pig, Cow

1437

KDIDIGKEYIIP

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry: In paraffin embedded Human Kidney shows membranous staining in DCT. Recommended concentration, 4-6ug/ml. Western Blot: Approx. 150kDa band observed in Human Brain (Frnotal Cortex) and Mouse Brain lysates (calculated MW of 161kDa according to NP_005679.2). Recommended concentration: 0.5-1.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: N Terminus. Immunogen: Peptide with sequence KDIDIGKEYIIP-C, from the N Terminus of the protein sequence according to NP_005679.2; NP_001018881.1. Corresponding Immunizing Peptide: Catalog #MBS426635

Important Note: This antibody is expected to recognize both reported isoforms (NP_005679.2; NP_001018881.1).

66529005

NP_005679.2

NM_005688.2

155,732 Da

ABC Transporters Pathway 83035!!ABC Transporters Pathway 436!!ABC-family Proteins Mediated Transport Pathway 106573!!Disease Pathway 530764!!Fluoropyrimidine Activity Pathway 198778!!Glycogen Storage Diseases Pathway 980468!!Glycosaminoglycan Metabolism Pathway 645297!!Hyaluronan Biosynthesis And Export Pathway 645299!!Hyaluronan Metabolism Pathway 645298!!MPS I - Hurler Syndrome Pathway 685537

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD