Goat anti-ACSL5 Antibody | MyBioSource MBS420316 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ACSL5 Antibody

catalog :

MBS420316

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420316

products type :

Antibody

products full name :

Goat anti-ACSL5 Antibody

products short name :

ACSL5

products name syn :

ACSL5; acyl-CoA synthetase long-chain family member 5; HGNC: 16526; ACS2; ACS5; FACL5; fatty-acid-Coenzyme A ligase, long-chain 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; ACSL5 antibody; acyl-CoA synthetase long-chain family member 5 antibody; HGNC: 16526 antibody; ACS2 antibody; ACS5 antibody; FACL5 antibody; fatty-acid-Coenzyme A ligase; long-chain 5 antibody; long-chain acyl-CoA synthetase 5 antibody; long-chain fatty acid coenzyme A ligase 5 antibody; ACSL5

other names :

long-chain-fatty-acid--CoA ligase 5 isoform a; Long-chain-fatty-acid--CoA ligase 5; long-chain-fatty-acid--CoA ligase 5; acyl-CoA synthetase long-chain family member 5; Long-chain acyl-CoA synthetase 5; LACS 5

products gene name :

ACSL5

other gene names :

ACSL5; ACSL5; ACS2; ACS5; FACL5; ACS5; FACL5; LACS 5

uniprot entry name :

ACSL5_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

739

sequence :

RTQIDSLYEHIQD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 75kDa band observed in human spleen lysates (calculated MW of 76. 0kDa according to NP_976313.1and NP_976314.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-RTQIDSLYEHIQD, from the C Terminus of the protein sequence according to NP_057318.2; NP_976313.1; NP_976314.1. Epitope: C Terminus

other info2 :

Note: This antibody is expected to recognise isoform a (NP_057318.2) and isoform b (NP_976313.1 and NP_976314.1).

ncbi gi num :

42794756

ncbi acc num :

NP_057318.2

ncbi gb acc num :

NM_016234.3

ncbi mol weight :

73,278 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid Biosynthesis Pathway (198873); Fatty Acyl-CoA Biosynthesis Pathway (1270012); Fatty Acid Biosynthesis Pathway (82933); Fatty Acid Biosynthesis Pathway (294); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296); Fatty Acid Metabolism Pathway (868084)

ncbi summary :

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ACSL5: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Ligase; EC 6.2.1.3; Membrane protein, integral; Lipid Metabolism - fatty acid; Mitochondrial. Chromosomal Location of Human Ortholog: 10q25.2. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; nucleolus; nucleus. Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity. Biological Process: long-chain fatty acid metabolic process

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage