Goat anti-Serotonin receptor 1B/HTR1B Antibody | MyBioSource MBS420311 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Serotonin receptor 1B/HTR1B Antibody

catalog :

MBS420311

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420311

products type :

Antibody

products full name :

Goat anti-Serotonin receptor 1B/HTR1B Antibody

products short name :

Serotonin receptor 1B/HTR1B

products name syn :

HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12; HTR1B antibody; 5-hydroxytryptamine (serotonin) receptor 1B antibody; 5-HT1B antibody; 5-HT1DB antibody; HTR1D2 antibody; HTR1DB antibody; S12 antibody; Serotonin receptor 1B; Serotonin receptor 1B / HTR1B

other names :

5-hydroxytryptamine receptor 1B; 5-hydroxytryptamine receptor 1B; 5-hydroxytryptamine receptor 1B; 5-hydroxytryptamine receptor 1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B

products gene name :

HTR1B

other gene names :

HTR1B; HTR1B; S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta; HTR1DB; 5-HT-1B; 5-HT1B; 5-HT-1D-beta

uniprot entry name :

5HT1B_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cat, Dog, Pig, Cow

sequence length :

390

sequence :

SNEDFKQAFHK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 48kDa band observed in Human Brain lysates (calculated MW of 43.6kDa according to NP_000854.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-SNEDFKQAFHK, from the C Terminus of the protein sequence according to NP_000854.1. Epitope: C Terminus

ncbi gi num :

4504533

ncbi acc num :

NP_000854.1

ncbi gb acc num :

NM_000863.2

ncbi mol weight :

43,568 Da

ncbi pathways :

Amine Ligand-binding Receptors Pathway (1269553); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (i) Signalling Events Pathway (1269576); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Monoamine GPCRs Pathway (198861); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Serotonergic Synapse Pathway (525336)

ncbi summary :

The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

uniprot summary :

5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 6q13. Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane. Molecular Function: drug binding; protein binding; serotonin binding; serotonin receptor activity. Biological Process: bone remodeling; drinking behavior; G-protein coupled receptor internalization; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP biosynthetic process; negative regulation of serotonin secretion; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; protein kinase C activation; regulation of behavior; regulation of dopamine secretion; response to cocaine; response to ethanol; response to mineralocorticoid stimulus; serotonin receptor, adenylate cyclase inhibiting pathway; synaptic transmission; vasoconstriction

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage