Goat anti-RXR beta Antibody | MyBioSource MBS420305 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-RXR beta Antibody

catalog :

MBS420305

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420305

products type :

Antibody

products full name :

Goat anti-RXR beta Antibody

products short name :

RXR beta

products name syn :

RXRB; NR2B2; DAUDI6; RCoR-1; MGC1831; H-2RIIBP; retinoid X receptor, beta; MHC class I promoter binding protein; DADB-100D22.1; RXRB antibody; NR2B2 antibody; DAUDI6 antibody; RCoR-1 antibody; MGC1831 antibody; H-2RIIBP antibody; retinoid X receptor; beta antibody; MHC class I promoter binding protein antibody; DADB-100D22.1 antibody; RXR beta

other names :

retinoic acid receptor RXR-beta isoform 2; Retinoic acid receptor RXR-beta; retinoic acid receptor RXR-beta; retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

products gene name :

RXRB

products gene name syn :

RXR beta

other gene names :

RXRB; RXRB; NR2B2; DAUDI6; RCoR-1; H-2RIIBP; NR2B2

uniprot entry name :

RXRB_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

533

sequence :

CRDGMGDSGRDSRSP

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 55kDa band observed in lysates of cell line A431 (calculated MW of 56.9kDa according to NP_068811.1). In transfected HEK293 transiently expressing RXRB a band of approx. 60kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence CRDGMGDSGRDSRSP, from the internal region of the protein sequence according to NP_068811.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise an epitope corresponding to aa 70-83 of human RXR beta protein and does not cross-react with either RXR alpha or gamma.

ncbi gi num :

11415052

ncbi acc num :

NP_068811.1

ncbi gb acc num :

NM_021976.4

ncbi mol weight :

57,365 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531); Nuclear Receptor Transcription Pathway (1269652); Nuclear Receptors Pathway (198848); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450)

ncbi summary :

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

RXRB: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Expressed in a variety of tumor cell lines. Belongs to the nuclear hormone receptor family. NR2 subfamily. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: nucleoplasm; nucleus. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; retinoic acid receptor binding; retinoid-X receptor activity; steroid hormone receptor activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription factor activity; vitamin D receptor binding; zinc ion binding. Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of myelination; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage