antibody

Goat anti-FBP17/FNBP1 Antibody

MBS420283

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-FBP17/FNBP1 Antibody

FBP17/FNBP1

FNBP1; FBP17; KIAA0554; formin binding protein 1; formin-binding protein 17; MGC126804; FNBP1 antibody; FBP17 antibody; KIAA0554 antibody; formin binding protein 1 antibody; formin-binding protein 17 antibody; MGC126804 antibody; FBP17 / FNBP1

formin-binding protein 1; Formin-binding protein 1; formin-binding protein 1; formin binding protein 1; Formin-binding protein 17; hFBP17

FNBP1

FBP17

FNBP1; FNBP1; FBP17; FBP17; KIAA0554; hFBP17

FNBP1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

617

KQLESSKRRFERDC

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 70kDa band observed in human testis lysates (calculated MW of 71.3kDa according to NP_055848.1). Recommended concentration: 0.25-2ug/ml.

Immunogen: Peptide with sequence KQLESSKRRFERDC, from the internal region of the protein sequence according to NP_055848.1. Epitope: Internal region

38524622

NP_055848.1

NM_015033.2

70,752 Da

The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]

FNBP1: May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation. Belongs to the FNBP1 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Actin-binding; Vesicle. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: cell cortex; coated pit; cytoplasmic membrane-bound vesicle; cytoskeleton; lysosome; plasma membrane; trans-Golgi network. Molecular Function: ARF guanyl-nucleotide exchange factor activity; identical protein binding; lipid binding; protein binding. Biological Process: endocytosis; positive regulation of GTPase activity; vesicle-mediated transport

0.1 mg

300 USD