catalog number :
MBS420273
products full name :
Goat anti-VDR Antibody
products short name :
VDR
products name syn :
VDR; vitamin D (1; 25- dihydroxyvitamin D3) receptor; HGNC:12679; NR1I1; vitamin D (1; 25-dihydroxyvitamin D3) receptor; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; HGNC:12679; NR1I1; vitamin D (1,25-dihydroxyvitamin D3) receptor
other names :
vitamin D3 receptor isoform VDRA; Vitamin D3 receptor; vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; vitamin D nuclear receptor variant 1; nuclear receptor subfamily 1 group I member 1; protein phosphatase 1, regulatory subunit 163; vitamin D (1,25- dihydroxyvitamin D3) receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
other gene names :
VDR; VDR; NR1I1; PPP1R163; NR1I1; VDR
uniprot entry name :
VDR_HUMAN
reactivity :
Human, Mouse, Rat, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 40-45kDa band observed in Human Brain lysates and in lysaes of Mouse and Rat Small Intestines (calculated MW of 48.3kDa according to NP_000367.1and NP_001017535.1. Recommended concentration: 0.3-1.0ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence CGNQDYKYRVSD, from the internal region of the protein sequence according to NP_000367.1; NP_001017535.1. Corresponding Immunizing Peptide: Catalog #MBS426581
other info2 :
Important Note: Both transcript variants (NP_000367; NP_001017535) encode the same protein.
ncbi acc num :
NP_000367.1
ncbi gb acc num :
NM_000376.2
ncbi mol weight :
53,883 Da
ncbi pathways :
Direct P53 Effectors Pathway 137939!!Drug Induction Of Bile Acid Pathway 698755!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213307!!Endocrine And Other Factor-regulated Calcium Reabsorption Pathway 213276!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Mineral Absorption Pathway 212237!!Mineral Absorption Pathway 212220!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848
ncbi summary :
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]