Goat anti-Triosephosphate isomerase Antibody | MyBioSource MBS420245 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Triosephosphate isomerase Antibody

catalog :

MBS420245

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420245

products type :

Antibody

products full name :

Goat anti-Triosephosphate isomerase Antibody

products short name :

Triosephosphate isomerase

products name syn :

Goat Anti-Triosephosphate isomerase, Biotinylated Antibody; TPI1; triosephosphate isomerase 1; TPI; MGC88108; triosephosphate isomerase 1 antibody; TPI1 antibody; TPI antibody; MGC88108 antibody; Triosephosphate isomerase; Triosephosphate isomerase

other names :

triosephosphate isomerase isoform 1; Triosephosphate isomerase; triosephosphate isomerase; triosephosphate isomerase 1; Triose-phosphate isomerase

products gene name :

TPI1

other gene names :

TPI1; TPI1; TIM; TPI; TPID; HEL-S-49; TPI; TIM

uniprot entry name :

TPIS_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

249

sequence :

LKPEFVDIINAKQ

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Liver shows staining of the sinusoids. Recommended concentration, 2-4ug/ml. Western Blot: Approx 26kDa band observed in human liver and human hepatoblastoma HepG2 cell lysates (calculated MW of 26.7kDa according to NP_000356). Recommended concentration: 0.01-0.03ug/ml.

other info1 :

Immunogen: Peptide with sequence C-LKPEFVDIINAKQ, from the C Terminus of the protein sequence according to NP_000356.1; NP_001152759.1. Epitope: C Terminus

other info2 :

Note: This antibody is expected to recognise reported isoforms 1 and 2 (NP_000356.1; NP_001152759.1).

ncbi gi num :

4507645

ncbi acc num :

NP_000356.1

ncbi gb acc num :

NM_000365.5

ncbi mol weight :

17,958 Da

ncbi pathways :

Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Fatty Acid Beta Oxidation Pathway (198865); Fructose And Mannose Metabolism Pathway (82930); Fructose And Mannose Metabolism Pathway (291); Gluconeogenesis Pathway (1269961); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (413342); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196)

ncbi summary :

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

uniprot summary :

TPI1: Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency). TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. Belongs to the triosephosphate isomerase family. 2 isoforms of the human protein are produced by alternative promoter. Protein type: Carbohydrate Metabolism - inositol phosphate; Carbohydrate Metabolism - fructose and mannose; Isomerase; EC 5.3.1.1; Carbohydrate Metabolism - glycolysis and gluconeogenesis. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: cytosol; extracellular space; nucleus. Molecular Function: protein binding; triose-phosphate isomerase activity; ubiquitin protein ligase binding. Biological Process: gluconeogenesis; glyceraldehyde-3-phosphate biosynthetic process; glycerol catabolic process; glycolysis; multicellular organismal development; pentose-phosphate shunt. Disease: Triosephosphate Isomerase Deficiency

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage