catalog number :
MBS420229
products full name :
Goat anti-FBXL12 Antibody
products short name :
FBXL12
products name syn :
FBXL12; likely ortholog of mouse f-box and leucine-rich repeat protein 12; FLJ20188; hypothetical protein FLJ20188; F-box and leucine-rich repeat protein 12; Fbl12; FBXL12; likely ortholog of mouse f-box and leucine-rich repeat protein 12; FLJ20188; hypothetical protein FLJ20188; F-box and leucine-rich repeat protein 12; Fbl12
other names :
F-box/LRR-repeat protein 12; F-box/LRR-repeat protein 12; F-box/LRR-repeat protein 12; F-box protein FBL12; F-box and leucine-rich repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12
products gene name :
FBXL12
other gene names :
FBXL12; FBXL12; Fbl12; FBL12
uniprot entry name :
FXL12_HUMAN
reactivity :
Human, Mouse, Rat, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Lung shows staining of ciliated epithelial cells in the bronchioles. Recommended concentration, 4-6ug/ml. Western Blot: Preliminary experiments gave no signal but low background in Human Brain lysates at up to 1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence RACPKESMDWWM, from the C Terminus of the protein sequence according to NP_060173.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425794
ncbi acc num :
NP_060173.1
ncbi gb acc num :
NM_017703.1
ncbi mol weight :
30,491 Da
ncbi summary :
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]