antibody

Goat anti-SEL1L Antibody

MBS420228

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-SEL1L Antibody

SEL1L

SEL1L; sel-1 suppressor of lin-12-like (C. elegans); IBD2; PRO1063; SEL1-LIKE; Suppressor of lin 12 (sel-1), C. elegans, homolog of; sel-1 (suppressor of lin-12, C. elegans)-like; sel-1 suppressor of lin-12-like; SEL1L antibody; sel-1 suppressor of lin-12-like (C. elegans) antibody; IBD2 antibody; PRO1063 antibody; SEL1-LIKE antibody; Suppressor of lin 12 (sel-1); C. elegans; homolog of antibody; sel-1 (suppressor of lin-12; C. elegans)-like antibody; sel-1 suppressor of lin-12-like antibody

protein sel-1 homolog 1 isoform 1; Protein sel-1 homolog 1; protein sel-1 homolog 1; SEL1L ERAD E3 ligase adaptor subunit; Suppressor of lin-12-like protein 1; Sel-1L

SEL1L

SEL1L; SEL1L; SEL1L1; PRO1063; SEL1-LIKE; TSA305; Sel-1L

SE1L1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

794

TAYNSYKDGDYN

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Approx 80kDa band observed in lysates of cell line HepG2 (calculated MW of 88.8kDa according to NP_005056.3). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence C-TAYNSYKDGDYN, from the internal region of the protein sequence according to NP_005056.3. Epitope: Internal region

19923669

NP_005056.3

NM_005065.5

33,530 Da

Asparagine N-linked Glycosylation Pathway (1268714); Calnexin/calreticulin Cycle Pathway (1268723); Disease Pathway (1268854); Diseases Of Signal Transduction Pathway (1268855); ER Quality Control Compartment (ERQC) Pathway (1268724); HRD1/SEL1 ERAD Complex Pathway (413468); HRD1/SEL1 ERAD Complex Pathway (468401); Hedgehog Ligand Biogenesis Pathway (1269634); Hh Mutants Abrogate Ligand Secretion Pathway (1268927); Hh Mutants That Don't Undergo Autocatalytic Processing Are Degraded By ERAD Pathway (1268928)

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SEL1L: May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Belongs to the sel-1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 14q31. Cellular Component: endoplasmic reticulum membrane; integral to membrane. Molecular Function: protein binding. Biological Process: ER-associated protein catabolic process; Notch signaling pathway; protein stabilization; retrograde protein transport, ER to cytosol

0.1 mg

300 USD