Goat anti-GLuR5/GRIK1 Antibody | MyBioSource MBS420225 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-GLuR5/GRIK1 Antibody

catalog :

MBS420225

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:200	Rutkowska Wlodarczyk I, Aller M, Valbuena S, Bologna J, PrÃ©zeau L, Lerma J. A proteomic analysis reveals the interaction of GluK1 ionotropic kainate receptor subunits with Go proteins. J Neurosci. 2015;35:5171-9 pubmed publisher

product information

catalog number :

MBS420225

products type :

Antibody

products full name :

Goat anti-GLuR5/GRIK1 Antibody

products short name :

GLuR5/GRIK1

products name syn :

GLUR5; GRIK1; glutamate receptor, ionotropic, kainate 1; EAA3; EEA3; GLR5; excitatory amino acid receptor 3; GLUR5 antibody; GRIK1 antibody; glutamate receptor; ionotropic; kainate 1 antibody; EAA3 antibody; EEA3 antibody; GLR5 antibody; excitatory amino acid receptor 3 antibody; GLuR5 / GRIK1

other names :

glutamate receptor ionotropic, kainate 1 isoform 1; Glutamate receptor ionotropic, kainate 1; glutamate receptor ionotropic, kainate 1; glutamate ionotropic receptor kainate type subunit 1; Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5

products gene name :

GRIK1

products gene name syn :

GLuR5

other gene names :

GRIK1; GRIK1; EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5; GLUR5; GluK1; EAA3; GluR-5; GluR5

uniprot entry name :

GRIK1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat

sequence length :

918

sequence :

QCKQTHPTNSTS

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000.

other info1 :

Immunogen: Peptide with sequence QCKQTHPTNSTS, from the internal region (near the C Terminus) of the protein sequence according to NP_000821.1; NP_783300.1. Epitope: Internal region (near the C Terminus)

other info2 :

Note: This antibody is expected to recognise both reported isoforms according to NP_000821.1 and NP_783300.1.

ncbi gi num :

4504117

ncbi acc num :

NP_000821.1

ncbi gb acc num :

NM_000830.4

ncbi mol weight :

102,631 Da

ncbi pathways :

Activation Of Ca-permeable Kainate Receptor Pathway (1268811); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (1268808); Activation Of Na-permeable Kainate Receptors Pathway (1268810); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Ionotropic Activity Of Kainate Receptors Pathway (1268809); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Neuronal System Pathway (1268763); Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway (1268786)

ncbi summary :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GluR5: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: cell junction; integral to plasma membrane; plasma membrane; postsynaptic membrane. Molecular Function: extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; ligand-gated ion channel activity. Biological Process: central nervous system development; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; nervous system development; regulation of synaptic transmission, glutamatergic; synaptic transmission; transport

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage