catalog number :
MBS420223
products full name :
Goat anti-PTF1A / PFT1-P48 Antibody
products short name :
PTF1A/PFT1-P48
products name syn :
PTF1A; PTF1-p48; pancreas specific transcription factor; 1a; bHLH transcription factor p48; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas transcription factor 1 subunit alpha; PTF1A; PTF1-p48; pancreas specific transcription factor, 1a; bHLH transcription factor p48; class II bHLH protein PTF1A; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas transcription factor 1 subunit alpha
other names :
pancreas transcription factor 1 subunit alpha; Pancreas transcription factor 1 subunit alpha; pancreas transcription factor 1 subunit alpha; class II bHLH protein PTF1A; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; pancreas-specific transcription factor 1a; exocrine pancreas-specific transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas specific transcription factor, 1a; Class A basic helix-loop-helix protein 29; bHLHa29; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; PTF1-p48
products gene name :
PTF1A
other gene names :
PTF1A; PTF1A; PACA; PAGEN2; bHLHa29; PTF1-p48; BHLHA29; PTF1P48; bHLHa29; PTF1-p48
uniprot entry name :
PTF1A_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Zebrafish
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 48kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 35.0kDa according to NP_835455.1). Recommended concentration: 0.5-1.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-WTDEKQLKEQN, from the internal region of the protein sequence according to NP_835455.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425390
ncbi acc num :
NP_835455.1
ncbi gb acc num :
NM_178161.2
ncbi mol weight :
34,970 Da
ncbi pathways :
Developmental Biology Pathway 477129!!Notch-mediated HES/HEY Network Pathway 169347!!Regulation Of Beta-cell Development Pathway 106328!!Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway 106329
ncbi summary :
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]