catalog number :
MBS420221
products full name :
Goat anti-TFE3 Antibody
products short name :
TFE3
products name syn :
TFE3; transcription factor binding to IGHM enhancer 3; Transcription factor for IgH enhancer; RCCP2; TFEA; bHLHe33; OTTHUMP00000024272; Renal cell carcinoma; papillary; Transcription factor for IgH enhancer; transcription factor E family; member A; transcription factor E3; TFE3; transcription factor binding to IGHM enhancer 3; Transcription factor for IgH enhancer; RCCP2; TFEA; bHLHe33; OTTHUMP00000024272; Renal cell carcinoma, papillary; Transcription factor for IgH enhancer; transcription factor E family, member A; transcription factor E3
other names :
transcription factor E3 isoform 1; Transcription factor E3; transcription factor E3; transcription factor for IgH enhancer; transcription factor E family, member A; class E basic helix-loop-helix protein 33; transcription factor for immunoglobulin heavy-chain enhancer 3; transcription factor binding to IGHM enhancer 3; Class E basic helix-loop-helix protein 33; bHLHe33
products gene name :
TFE3
other gene names :
TFE3; TFE3; TFEA; RCCP2; RCCX1; bHLHe33; BHLHE33; bHLHe33
uniprot entry name :
TFE3_HUMAN
reactivity :
Human, Mouse, Dog, Cow
sequence :
SHAAEPARDGVEAS
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 60kDa band observed in lysates of HEK293 (calculated MW of 61.5kDa according to NP_006512.2). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence SHAAEPARDGVEAS-C, from the N Terminus of the protein sequence according to NP_006512.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426553
ncbi acc num :
NP_006512.2
ncbi gb acc num :
NM_006521.5
ncbi mol weight :
11,363 Da
ncbi pathways :
E2F Transcription Factor Network Pathway 137934!!Regulation Of Nuclear SMAD2/3 Signaling Pathway 137963!!TGF Beta Signaling Pathway 198810!!Transcriptional Misregulation In Cancer Pathway 523016!!Transcriptional Misregulation In Cancer Pathway 522987
ncbi summary :
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]