catalog number :
MBS420200
products full name :
Goat anti-DOPA decarboxylase Antibody
products short name :
DOPA decarboxylase
products name syn :
dopa decarboxylase (aromatic L-amino acid decarboxylase); HGNC:2719; DDC; AADC; aromatic L-amino acid decarboxylase; DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); HGNC:2719; AADC; aromatic L-amino acid decarboxylase
other names :
aromatic-L-amino-acid decarboxylase isoform 1; Aromatic-L-amino-acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); DOPA decarboxylase; DDC
other gene names :
DDC; DDC; AADC; AADC; AADC; DDC
uniprot entry name :
DDC_HUMAN
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 50kDa band observed in Human Kidney lysates and 48kDa on Human Brain lysates (calculated MW of 53.9kDa according to NP_000781.1). Recommended concentration: 0.03-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-WEHIKELAADVL, from the C Terminus of the protein sequence according to NP_000781.1; NP_001229815.1; NP_001229816.1; NP_001229817.1; NP_001229818.1. Corresponding Immunizing Peptide: Catalog #MBS425713
other info2 :
Important Note: This antibody is expected to recognise isoforms 1, 2, 3, 4 and 5 (NP_000781.1; NP_001229815.1; NP_001229816.1; NP_001229817.1; NP_001229818.1 respectively). Reported variants represent identical protein (NP_000781.1; NP_001076440.1).
ncbi acc num :
NP_000781.1
ncbi gb acc num :
NM_000790.3
ncbi mol weight :
44,239 Da
ncbi pathways :
Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Amine-derived Hormones Pathway 160983!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!Biogenic Amine Synthesis Pathway 198793!!Catecholamine Biosynthesis Pathway 160984!!Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway 413357!!Catecholamine Biosynthesis, Tyrosine = Dopamine = Noradrenaline = Adrenaline Pathway 468235!!Cocaine Addiction Pathway 546258
ncbi summary :
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]