antibody

Goat anti-UCP1 Antibody

MBS420174

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, enzyme immunoassay

Antibody

Goat anti-UCP1 Antibody

UCP1

UCP1; uncoupling protein 1 (mitochondrial, proton carrier); HGNC: 12517; SLC25A7; UCP; mitochondrial brown fat uncoupling protein; uncoupling protein 1; UCP1 antibody; uncoupling protein 1 (mitochondrial; proton carrier) antibody; HGNC: 12517 antibody; SLC25A7 antibody; UCP antibody; mitochondrial brown fat uncoupling protein antibody; uncoupling protein 1 antibody

mitochondrial brown fat uncoupling protein 1; Mitochondrial brown fat uncoupling protein 1; mitochondrial brown fat uncoupling protein 1; uncoupling protein 1; Solute carrier family 25 member 7; Thermogenin

UCP1

UCP1; UCP1; UCP; SLC25A7; SLC25A7; UCP; UCP 1

UCP1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

307

EQLKRELSKSRQ

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 35kDa band observed in Human Adipose lysates (calculated MW of 33. 0kDa according to NP_068605.1). Recommended concentration: 0.1-1 ug/ml.

Immunogen: Peptide with sequence C-EQLKRELSKSRQ, from the C Terminus of the protein sequence according to NP_068605.1. Epitope: C Terminus

11225256

NP_068605.1

NM_021833.4

33,005 Da

Adipogenesis Pathway (198832); Electron Transport Chain Pathway (198860); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (1269956); Mitochondrial Uncoupling Proteins Pathway (1270130); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway (1270127); The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway (1270121)

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

UCP1: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Belongs to the mitochondrial carrier family. Protein type: Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 4q28-q31. Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion. Molecular Function: oxidative phosphorylation uncoupler activity; structural constituent of ribosome. Biological Process: brown fat cell differentiation; mitochondrial transport; proton transport; regulation of transcription from RNA polymerase II promoter; translation. Disease: Obesity

0.1 mg

300 USD