antibody

Goat anti-FOXP3/Scurfin (Mouse) Antibody

MBS420161

0.1 mg

300 USD

polyclonal

goat

nonconjugated

mouse, rat

immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-FOXP3/Scurfin (Mouse) Antibody

FOXP3/Scurfin

Foxp3; forkhead box P3; sf; JM2; scurfin; scurfy; RP23-54C14.1; OTTMUSP00000017952; OTTMUSP00000017961; OTTMUSP00000017962; Foxp3 antibody; forkhead box P3 antibody; sf antibody; JM2 antibody; scurfin antibody; scurfy antibody; RP23-54C14.1 antibody; OTTMUSP00000017952 antibody; OTTMUSP00000017961 antibody; OTTMUSP00000017962 antibody; Scurfin; FOXP3 / Scurfin (Mouse)

forkhead box protein P3; Forkhead box protein P3; forkhead box protein P3; forkhead box P3; Scurfin

Foxp3

Foxp3; Foxp3; sf; JM2; scurfin

FOXP3_MOUSE

Polyclonal

Goat

Tested: Mouse; Expected from sequence similarity: Mouse, Rat

429

KRSQRPNKCSNP

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Immunohistochemistry (IHC)

Peptide ELISA: Antibody detection limit dilution 1: 4000. Immunohistochemistry: In paraffin embedded Mouse Thymus shows nuclear staining in some patches of thymocytes. Recommended concentration, 2-4ug/ml.

Immunogen: Peptide with sequence KRSQRPNKCSNP, from the C Terminus of the protein sequence according to NP_473380.1. Epitope: C Terminus

16905075

NP_473380.1

NM_054039.2

47,346 Da

Inflammatory Bowel Disease (IBD) Pathway (842778); Inflammatory Bowel Disease (IBD) Pathway (842797)

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Cell cycle regulation; DNA-binding; C2H2-type zinc finger protein. Cellular Component: cytoplasm; intracellular; nucleus. Molecular Function: DNA binding; histone acetyltransferase binding; histone deacetylase binding; metal ion binding; NFAT protein binding; nucleic acid binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity. Biological Process: B cell homeostasis; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; cytokine production; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; myeloid cell homeostasis; negative regulation of cell proliferation; negative regulation of chronic inflammatory response; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone acetylation; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of interleukin-6 production; negative regulation of isotype switching to IgE isotypes; negative regulation of lymphocyte proliferation; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of immature T cell proliferation in the thymus; positive regulation of interleukin-4 production; positive regulation of peripheral T cell tolerance induction; positive regulation of regulatory T cell differentiation; positive regulation of T cell anergy; positive regulation of T cell tolerance induction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor-beta1 production; regulation of immunoglobulin production; regulation of isotype switching to IgG isotypes; regulation of T cell anergy; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulatory T cell differentiation; T cell activation; T cell mediated immunity; T cell receptor signaling pathway; tolerance induction; tolerance induction to self antigen; transcription, DNA-dependent

0.1 mg

300 USD