catalog number :
MBS420143
products full name :
Goat anti-ACADM Antibody
products short name :
ACADM
products name syn :
ACADM; acyl-Coenzyme A dehydrogenase; C-4 to C-12 straight chain; RP4-682C21.1; ACAD1; MCAD; MCADH; medium-chain acyl-CoA dehydrogenase; FLJ18227; FLJ93013; FLJ99884; medium-chain specific acyl-CoA dehydrogenase; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; RP4-682C21.1; ACAD1; MCAD; MCADH; medium-chain acyl-CoA dehydrogenase; FLJ18227; FLJ93013; FLJ99884; medium-chain specific acyl-CoA dehydrogenase
other names :
medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a; Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain; acyl-CoA dehydrogenase, C-4 to C-12 straight chain
products gene name :
ACADM
other gene names :
ACADM; ACADM; MCAD; ACAD1; MCADH; MCAD
uniprot entry name :
ACADM_HUMAN
sequence :
RLIVAREHIDKYKN
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Liver shows mitochondrial staining in hepatocytes. Recommended concentration, 3-5ug/ml. Western Blot: Approx 45kDa band observed in Human Kidney and Heart lysates (calculated MW of 46.6kDa according to NP_000007.1). Recommended for use at 0.01-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-RLIVAREHIDKYKN, from the C Terminus of the protein sequence according to NP_000007.1; NP_001120800.1. Corresponding Immunizing Peptide: Catalog #MBS426384
other info2 :
Important Note: This antibody is expected to recognise both reported isoforms.
ncbi acc num :
NP_000007.1
ncbi gb acc num :
NM_000016.5
ncbi mol weight :
47,020 Da
ncbi pathways :
Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway 106127!!Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway 106128!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Fatty Acid Beta Oxidation Pathway 198865!!Fatty Acid Degradation Pathway 82935!!Fatty Acid Degradation Pathway 296!!Fatty Acid Metabolism Pathway 868084!!Fatty Acid Metabolism Pathway 878045
ncbi summary :
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]