Goat anti-Ezrin/villin 2 Antibody | MyBioSource MBS420129 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Ezrin/villin 2 Antibody

catalog :

MBS420129

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420129

products type :

Antibody

products full name :

Goat anti-Ezrin/villin 2 Antibody

products short name :

Ezrin/villin 2

products name syn :

villin 2 (ezrin); ezrin; VIL2; CVIL; CVL; DKFZp762H157; FLJ26216; MGC1584; cytovillin; villin 2; villin 2 (ezrin) antibody; ezrin antibody; VIL2 antibody; CVIL antibody; CVL antibody; DKFZp762H157 antibody; FLJ26216 antibody; MGC1584 antibody; cytovillin antibody; villin 2 antibody; Ezrin; Villin 2; Ezrin / villin 2

other names :

ezrin; Ezrin; ezrin; ezrin; Cytovillin; Villin-2; p81

products gene name :

VIL2

other gene names :

EZR; EZR; CVL; CVIL; VIL2; HEL-S-105; VIL2

uniprot entry name :

EZRI_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Dog

sequence length :

586

sequence :

QDYEEKTKKAER

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: In paraffin embedded Human Small Intestine shows strong staining of enterocytes. Recommended concentration, 3-5ug/ml. Western Blot: Approx 80kDa band observed in Human Duodenum and Placenta lysates (calculated MW of 69.4kDa according to NP_003370.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Zhu et al, Am J Physiol Cell Physiol.2005 Jun;288(6): C1242-54.; PMID: 15788482). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-QDYEEKTKKAER, from the internal region of the protein sequence according to NP_003370.2. Epitope: Internal region

ncbi gi num :

21614499

ncbi acc num :

NP_003370.2

ncbi gb acc num :

NM_003379.4

ncbi mol weight :

69,413 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Axon Guidance Pathway (1270303); Developmental Biology Pathway (1270302); FAS (CD95) Signaling Pathway (138081); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); L1CAM Interactions Pathway (1270323); LKB1 Signaling Events Pathway (137957); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494)

ncbi summary :

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell projection; cortical cytoskeleton; cytoplasm; cytosol; endosome; extracellular space; extrinsic to membrane; filopodium; focal adhesion; immunological synapse; membrane; microvillus; microvillus membrane; myelin sheath; nucleolus; perinuclear region of cytoplasm; plasma membrane; ruffle; T-tubule; uropod; vesicle. Molecular Function: actin binding; actin filament binding; ATPase binding; cell adhesion molecule binding; microtubule binding; protein binding; protein domain specific binding. Biological Process: actin cytoskeleton reorganization; actin filament bundle formation; astral microtubule organization and biogenesis; axon guidance; cortical microtubule organization and biogenesis; cytoskeletal anchoring; D-glucose absorption; establishment of centrosome localization; establishment of epithelial cell polarity; filopodium formation; gland morphogenesis; leukocyte adhesion; membrane to membrane docking; microvillus biogenesis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; positive regulation of multicellular organism growth; positive regulation of protein secretion; receptor internalization; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of cell size; regulation of microvillus length

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage