product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-M6PR Antibody
catalog :
MBS420113
quantity :
0.1 mg
price :
225 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, cow
application :
ELISA, enzyme immunoassay
more info or order :
product information
catalog number :
MBS420113
products type :
Antibody
products full name :
Goat anti-M6PR Antibody
products short name :
M6PR
products name syn :
M6PR; mannose-6-phosphate receptor (cation dependent); CD-MPR; FLJ32994; MPR46; SMPR; 46-kDa mannose 6-phosphate receptor; Mr 46,000 Man6PR; cation-dependent mannose-6-phosphate receptor; M6PR antibody; mannose-6-phosphate receptor (cation dependent) antibody; CD-MPR antibody; FLJ32994 antibody; MPR46 antibody; SMPR antibody; 46-kDa mannose 6-phosphate receptor antibody; Mr 46; 000 Man6PR antibody; cation-dependent mannose-6-phosphate receptor antibody
other names :
cation-dependent mannose-6-phosphate receptor isoform 1; Cation-dependent mannose-6-phosphate receptor; cation-dependent mannose-6-phosphate receptor; mannose-6-phosphate receptor, cation dependent; 46 kDa mannose 6-phosphate receptor; MPR 46
products gene name :
M6PR
other gene names :
M6PR; M6PR; SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR; MPR46; MPRD; CD Man-6-P receptor; CD-MPR; MPR 46
uniprot entry name :
MPRD_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
sequence length :
277
sequence :
KGGDEYDNHCGKEQ
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave bands at approx 70kDa and 35kDa in Human Lymph Node and Thyroid Gland lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 31. 0kDa according to NP_002346.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
other info1 :
Immunogen: Peptide with sequence KGGDEYDNHCGKEQ, from the internal region of the protein sequence according to NP_002346.1. Epitope: Internal region
ncbi gi num :
4505061
ncbi acc num :
NP_002346.1
ncbi gb acc num :
NM_002355.3
ncbi mol weight :
30,993 Da
ncbi pathways :
Clathrin Derived Vesicle Budding Pathway (1269881); Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway (1383038); Lysosome Pathway (99052); Lysosome Pathway (96865); Lysosome Vesicle Biogenesis Pathway (1269883); Membrane Trafficking Pathway (1269877); Phagosome Pathway (153910); Phagosome Pathway (153859); Retrograde Transport At The Trans-Golgi-Network Pathway (1383039); Vesicle-mediated Transport Pathway (1269876)
ncbi summary :
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
uniprot summary :
M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: endosome; integral to plasma membrane; late endosome; lysosomal membrane; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane; transport vesicle. Molecular Function: mannose binding; mannose transmembrane transporter activity; transmembrane receptor activity. Biological Process: endosome to lysosome transport; mannose transport; receptor-mediated endocytosis; signal transduction
size1 :
0.1 mg
price1 :
225 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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