antibody

Goat anti-DDB1 Antibody

MBS420103

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, enzyme immunoassay

Antibody

Goat anti-DDB1 Antibody

DDB1

DDB1; damage-specific DNA binding protein 1; 127kDa; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; DDB p127 subunit; damage-specific DNA binding protein 1 (127kD); XPE; DDB1; damage-specific DNA binding protein 1, 127kDa; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; DDB p127 subunit; damage-specific DNA binding protein 1 (127kD); XPE

DNA damage-binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein 1; XAP-1; UV-DDB 1; DDB p127 subunit; XPE-binding factor; HBV X-associated protein 1; DNA damage-binding protein a; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; xeroderma pigmentosum group E-complementing protein; damage-specific DNA binding protein 1, 127kDa; DDB p127 subunit; DNA damage-binding protein a; DDBa; Damage-specific DNA-binding protein 1; HBV X-associated protein 1; XAP-1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; XPE-binding factor; XPE-BF; Xeroderma pigmentosum group E-complementing protein; XPCe

DDB1

DDB1; DDB1; XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; XAP1; DDBa; XAP-1; UV-DDB 1; XPE-BF; XPCe

DDB1_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Cow

1140

DLIKVVEELTRIH

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 130kDa band seen in HeLa, Jurkat and NSO (mouse) cell lysates. Recommended for use at 0.5-1.5 ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: C Terminus. Immunogen: Peptide with sequence C-DLIKVVEELTRIH, from the C Terminus of the protein sequence according to NP_001914.3.

Corresponding Immunizing Peptide: Catalog #MBS426878

148529014

NP_001914.3

NM_001923.4

50,611 Da

Cul4-DDB1-CSA Complex Pathway 413453!!Cul4-DDB1-CSA Complex Pathway 890609!!Cul4-DDB1-DDB2 Complex Pathway 413452!!Cul4-DDB1-DDB2 Complex Pathway 890608!!DNA Repair Pathway 105837!!Dual Incision Reaction In GG-NER Pathway 105887!!Formation Of Incision Complex In GG-NER Pathway 105886!!Global Genomic NER (GG-NER) Pathway 105884!!Hepatitis B Pathway 694606!!Nucleotide Excision Repair Pathway 105883

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]

0.1 mg

290 USD