antibody

Goat anti-FOXP2 (internal) Antibody

MBS420097

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, rat, dog, cow

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-FOXP2 (internal) Antibody

FOXP2

FOXP2; forkhead box P2; CAGH44; DKFZp686H1726; SPCH1; TNRC10; CAG repeat protein 44; forkhead/winged-helix transcription factor; speech and language disorder 1; trinucleotide repeat containing 10; Goat Anti-FOXP2 (C terminus); FOXP2; forkhead box P2; CAGH44; DKFZp686H1726; SPCH1; TNRC10; CAG repeat protein 44; forkhead/winged-helix transcription factor; speech and language disorder 1; trinucleotide repeat containing 10

forkhead box protein P2 isoform I; Forkhead box protein P2; forkhead box protein P2; CAG repeat protein 44; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; trinucleotide repeat-containing gene 10 protein; forkhead box P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein

FOXP2

FOXP2; FOXP2; SPCH1; CAGH44; TNRC10; CAGH44; TNRC10

FOXP2_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Cat, Dog, Pig, Cow, Zebrafish

715

DEVEYQKRRSQKIT

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry: In paraffin embedded Human Prostate shows nuclear staining in the secretory cells. Recommended concentration, 2-4ug/ml. Western Blot: Approx 85kDa band observed in Human Brain (Cerebellum and Frontal Cortex) lysates and in Rat Brain lysates (calculated MW of 82.6kDa according to NP_683696.1). Recommended concentration: 0.3-1ug/ml. An additional band of unknown identity was also consistently observed at 28-30kDa. This band was successfully blocked by incubation with the immunising peptide. Peptide ELISA: antibody detection limit dilution 1:64000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-DEVEYQKRRSQKIT, from the internal region of the protein sequence according to NP_055306.1; NP_683696.2; NP_683697.2; NP_683698.2; NP_001166237.1. Corresponding Immunizing Peptide: Catalog #MBS425236

Important Note: This antibody is expected to recognize isoform I (NP_055306.1), isoform II (NP_683696.2), isoform IV (NP_683698.2) and isoform V (NP_001166237.1).

17017963

NP_055306.1

NM_014491.3

81,840 Da

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

0.1 mg

290 USD