catalog number :
MBS420095
products full name :
Goat anti-CBX1 / HP1-Beta Antibody
products short name :
CBX1/HP1-Beta
products name syn :
CBX1; HP1-BETA; chromobox homolog 1 (HP1 beta homolog Drosophila); HGNC:1551; CBX; HP1Hs-beta; M31; MOD1; chromobox homolog 1 (Drosophila HP1 beta); heterochromatin protein p25 beta; HP1Hsbeta; p25beta; heterochromatin protein 1-beta; modifier 1 protein; CBX1; HP1-BETA; chromobox homolog 1 (HP1 beta homolog Drosophila); HGNC:1551; CBX; HP1Hs-beta; M31; MOD1; chromobox homolog 1 (Drosophila HP1 beta); heterochromatin protein p25 beta; HP1Hsbeta; p25beta; heterochromatin protein 1-beta; modifier 1 protein
other names :
chromobox protein homolog 1; Chromobox protein homolog 1; chromobox protein homolog 1; HP1 beta homolog; modifier 1 protein; heterochromatin protein 1-beta; heterochromatin protein p25 beta; heterochromatin protein 1 homolog beta; chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox homolog 1; HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta
products gene name :
CBX1
other gene names :
CBX1; CBX1; CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; CBX; HP1 beta
uniprot entry name :
CBX1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Placenta shows strong nuclear staining in trophoblasts. Recommended concentration, 2-3ug/ml. Western Blot: Approx. 25kDa band observed in lysates of A431, HeLa and HepG2 (calculated MW of 25kDa according to NP_006798.1). Recommended concentration: 0.3-1.0 ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-QSQKTAHETDKSE, from the internal region of the protein sequence according to NP_006798.1; NP_001120700.1. Corresponding Immunizing Peptide: Catalog #MBS426391
other info2 :
Important Note: Variants (NP_006798.1; NP_001120700.1) encode the same protein.
ncbi acc num :
NP_006798.1
ncbi gb acc num :
NM_006807.4
ncbi mol weight :
21,418 Da
ncbi summary :
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]