antibody

Goat anti-Adenosine A2a Receptor Antibody

MBS420075

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, Rhesus monkey

western blot, enzyme immunoassay

Antibody

Goat anti-Adenosine A2a Receptor Antibody

Adenosine A2a Receptor

ADORA2A; adenosine A2a receptor; HGNC:263; ADORA2; RDC8; hA2aR; adenosine A2 receptor; adenosine receptor subtype A2a; adenosine A2a receptor; HGNC:263; ADORA2; RDC8; hA2aR; adenosine A2 receptor; adenosine receptor subtype A2a

adenosine receptor A2a; Adenosine receptor A2a; adenosine receptor A2a; adenosine receptor subtype A2a; adenosine A2a receptor

ADORA2A

ADORA2A; ADORA2A; A2aR; RDC8; ADORA2; ADORA2

AA2AR_HUMAN

Polyclonal

Goat

Human, Rhesus

412

HELKGVCPEPPGLDD

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: This antibody has been successfully used on lysates of primary Rhesus microglia in Van der Putten et al, PMID: 19494284. Peptide ELISA: antibody detection limit dilution 1:8000.

Epitope: C Terminus. Immunogen: Peptide with sequence HELKGVCPEPPGLDD, from the C Terminus of the protein sequence according to NP_000666.2.

Corresponding Immunizing Peptide: Catalog #MBS426894

5921992

NP_000666.2

NM_000675.5

44,707 Da

Activation Of TRKA Receptors Pathway 106456!!Adenosine P1 Receptors Pathway 106375!!Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

0.1 mg

290 USD