catalog number :
MBS420053
products full name :
Goat anti-HYPB / SETD2 (internal region) Antibody
products short name :
HYPB/SETD2
products name syn :
SETD2; SET domain containing 2; FLJ16420; FLJ22472; FLJ23184; FLJ45883; HIF-1; HSPC069; HYPB; KIAA1732; huntingtin interacting protein 1; huntingtin interacting protein B; Goat Anti-HYPB / SETD2 (C Terminus); SETD2; SET domain containing 2; FLJ16420; FLJ22472; FLJ23184; FLJ45883; HIF-1; HSPC069; HYPB; KIAA1732; huntingtin interacting protein 1; huntingtin interacting protein B
other names :
histone-lysine N-methyltransferase SETD2; Histone-lysine N-methyltransferase SETD2; histone-lysine N-methyltransferase SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B; SET domain containing 2; HIF-1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; HIP-1; Huntingtin-interacting protein B; Lysine N-methyltransferase 3A; SET domain-containing protein 2; hSET2; p231HBP
products gene name :
SETD2
other gene names :
SETD2; SETD2; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; HIF1; HYPB; KIAA1732; KMT3A; SET2; HIP-1; hSET2
uniprot entry name :
SETD2_HUMAN
reactivity :
Human, Mouse, Dog, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 290kDa band observed in lysates of mouse fibroblasts. The observed band is knocked down by two different siRNA molecules. Calculated MW of 231kDa according to NP_054878.3). Data obtained from anonymous customer. The Ponceau red demonstrates proper protein loading. Recommended concentration: 0.5-2ug/ml. Peptide ELISA: antibody detection limit dilution 1:4000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-ERDPDKQTQNKE, from the internal region of the protein sequence according to NP_054878.5.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426506
ncbi acc num :
NP_054878.5
ncbi gb acc num :
NM_014159.6
ncbi mol weight :
175,982 Da
ncbi pathways :
Lysine Degradation Pathway 82956!!Lysine Degradation Pathway 320
ncbi summary :
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]