catalog number :
MBS420050
products full name :
Goat anti-KLK5 Antibody
products short name :
KLK5
products name syn :
KLK5; kallikrein-related peptidase 5; KLK-L2; KLKL2; SCTE; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme; KLK5 antibody; kallikrein-related peptidase 5 antibody; KLK-L2 antibody; KLKL2 antibody; SCTE antibody; kallikrein 5 antibody; kallikrein-like protein 2 antibody; stratum corneum tryptic enzyme antibody
other names :
kallikrein-5 preproprotein; Kallikrein-5; kallikrein-5; kallikrein related peptidase 5; Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme
products gene name :
KLK5
other gene names :
KLK5; KLK5; SCTE; KLKL2; KLK-L2; SCTE; KLK-L2
uniprot entry name :
KLK5_HUMAN
reactivity :
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 1000. Western Blot: Approx 35kDa band observed in Human Brain (Cerebellum), Mouse Brain and Rat Brain lysates (calculated MW of 32. 0kDa according to NP_036559.1). Recommended concentration: 1-3ug/ml.
other info1 :
Immunogen: Peptide with sequence KAGRDSCQGD, from the internal region of the protein sequence according to NP_036559.1. Epitope: Internal region
other info2 :
Note: Reported variants represent identical protein (NP_036559.1; NP_001070959.1; NP_001070960.1).
ncbi acc num :
NP_036559.1
ncbi gb acc num :
NM_012427.4
ncbi mol weight :
32,019 Da
ncbi summary :
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
uniprot summary :
KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily. Protein type: Secreted; EC 3.4.21.-; Protease; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: extracellular space. Molecular Function: peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity. Biological Process: epidermis development; positive regulation of antibacterial peptide production; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis