Goat anti-SMO (C Terminus) Antibody | MyBioSource MBS420043 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-SMO (C Terminus) Antibody

catalog :

MBS420043

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420043

products type :

Antibody

products full name :

Goat anti-SMO (C Terminus) Antibody

products short name :

SMO

products name syn :

Goat Anti-SMO (internal) Antibody; SMO; smoothened homolog (Drosophila); HGNC: 11119; Gx; SMOH; seven transmembrane helix receptor; smoothened; SMO antibody; smoothened homolog (Drosophila) antibody; HGNC: 11119 antibody; Gx antibody; SMOH antibody; seven transmembrane helix receptor antibody; smoothened antibody; SMO (C Terminus)

other names :

smoothened homolog; Smoothened homolog; smoothened homolog; smoothened, frizzled class receptor; Protein Gx

products gene name :

SMO

other gene names :

SMO; SMO; Gx; SMOH; FZD11; SMOH; SMO

uniprot entry name :

SMO_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Dog, Cow

sequence length :

787

sequence :

NLMDTELMDADSD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 60kDa band observed in Human Bone Marrow lysates (calculated MW of 86.4kDa according to NP_005622.1).

other info1 :

Immunogen: Peptide with sequence C-NLMDTELMDADSD, from the C Terminus of the protein sequence according to NP_005622.1. Epitope: C Terminus

ncbi gi num :

5032099

ncbi acc num :

NP_005622.1

ncbi gb acc num :

NM_005631.4

ncbi mol weight :

86,397 Da

ncbi pathways :

Activation Of SMO Pathway (1269642); Assembly Of The Primary Cilium Pathway (1268846); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); BBSome-mediated Cargo-targeting To Cilium Pathway (1268850); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Cargo Trafficking To The Periciliary Membrane Pathway (1268848); Class B/2 (Secretin Family Receptors) Pathway (1269570); GPCR Ligand Binding Pathway (1269544)

ncbi summary :

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

uniprot summary :

SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family. Protein type: Membrane protein, multi-pass; Oncoprotein; Cell development/differentiation; Receptor, GPCR; Membrane protein, integral; GPCR, Fz/Smo family. Chromosomal Location of Human Ortholog: 7q32.3. Cellular Component: caveola; Golgi apparatus; integral to membrane; intracellular membrane-bound organelle; plasma membrane. Molecular Function: drug binding; G-protein coupled receptor activity; patched binding; protein binding; Wnt receptor activity; Wnt-protein binding. Biological Process: activation of hh target transcription factor; anterior/posterior pattern formation; astrocyte activation; cell fate specification; central nervous system neuron differentiation; cerebellar cortex morphogenesis; cerebral cortex development; dentate gyrus development; dorsoventral neural tube patterning; forebrain morphogenesis; G-protein coupled receptor protein signaling pathway; hair follicle morphogenesis; heart looping; homeostasis of number of cells within a tissue; in utero embryonic development; midgut development; multicellular organism growth; myoblast migration; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of epithelial cell differentiation; negative regulation of hair follicle development; negative regulation of transcription from RNA polymerase II promoter; neural crest cell migration; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of multicellular organism growth; positive regulation of neuroblast proliferation; positive regulation of organ growth; positive regulation of protein import into nucleus; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein stabilization; skeletal muscle fiber development; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; smoothened signaling pathway in ventral spinal cord patterning; thalamus development; vasculogenesis; ventral midline determination; Wnt receptor signaling pathway through beta-catenin

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage