catalog number :
MBS420042
products full name :
Goat anti-SORBS1/ponsin (internal region) Antibody
products short name :
SORBS1/ponsin
products name syn :
SORBS1; sorbin and SH3 domain containing 1; CAP; DKFZp451C066; DKFZp586P1422; FLAF2; FLJ12406; KIAA1296; R85FL; SH3D5; SH3P12; SORB1; Fas-ligand associated factor 2; SH3-domain protein 5; SH3-domain protein 5 (ponsin); c-Cbl associated protein; ponsin; Goat Anti-SORBS1 / ponsin (internal); SORBS1; sorbin and SH3 domain containing 1; CAP; DKFZp451C066; DKFZp586P1422; FLAF2; FLJ12406; KIAA1296; R85FL; SH3D5; SH3P12; SORB1; Fas-ligand associated factor 2; SH3-domain protein 5; SH3-domain protein 5 (ponsin); c-Cbl associated protein; ponsin
other names :
sorbin and SH3 domain-containing protein 1 isoform 1; Sorbin and SH3 domain-containing protein 1; sorbin and SH3 domain-containing protein 1; SORBS1; ponsin; SH3 domain protein 5; c-Cbl associated protein; Fas-ligand associated factor 2; sorbin and SH3 domain containing 1; Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP
products gene name :
SORBS1
other gene names :
SORBS1; SORBS1; CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12; CAP
uniprot entry name :
SRBS1_HUMAN
reactivity :
Human, Mouse
sequence :
SERNDWEPPDKKVD
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA)
app notes :
Western Blot: Preliminary experiments gave an approx 65kDa band in Human Adipose lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 76.6kDa according to NP_006425.2 and higher sizes for other isoforms. The 65kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-SERNDWEPPDKKVD, from the internal region of the protein sequence according to NP_006425.2; NP_056200.1; NP_001030126.1; NP_001030127.1; NP_001030128.1; NP_079267.1; NP_001030129.1. Corresponding Immunizing Peptide: Catalog #MBS425729
other info2 :
Important Note: This antibody is expected to recognise all reported isoforms (NP_006425.2 and NP_056200.1 and NP_001030126.1 and NP_001030127.1 and NP_001030128.1 and NP_079267.1 and NP_001030129.1)
ncbi acc num :
NP_006425.2
ncbi gb acc num :
NM_006434.2
ncbi mol weight :
143,741 Da
ncbi pathways :
Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Insulin Pathway 138026!!Insulin Signaling Pathway 198845!!Insulin Signaling Pathway 83090!!Insulin Signaling Pathway 501!!Integrin-mediated Cell Adhesion Pathway 198816!!Muscle Contraction Pathway 106261!!PPAR Signaling Pathway 83042!!PPAR Signaling Pathway 450
ncbi summary :
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]