Goat anti-Pancreatic Polypeptide/PPY Antibody | MyBioSource MBS420040 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Pancreatic Polypeptide/PPY Antibody

catalog :

MBS420040

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420040

products type :

Antibody

products full name :

Goat anti-Pancreatic Polypeptide/PPY Antibody

products short name :

Pancreatic Polypeptide/PPY

products name syn :

PPY; pancreatic polypeptide; HGNC: 9327; PNP; pancreatic polypeptide Y; PPY antibody; pancreatic polypeptide antibody; HGNC: 9327 antibody; PNP antibody; pancreatic polypeptide Y antibody; Pancreatic Polypeptide; Pancreatic Polypeptide / PPY

other names :

pancreatic prohormone isoform 1 preproprotein; Pancreatic prohormone; pancreatic prohormone; pancreatic polypeptide; Pancreatic polypeptide; PP

products gene name :

PPY

other gene names :

PPY; PPY; PP; PNP; PNP; PP; PH; PI

uniprot entry name :

PAHO_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

sequence :

TRPRYGKRHKEDT

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded human pancreas, shows strong cytoplasmic staining of rare cells located at the periphery of islets of Langerhans. Recommended concentration, 3ug/ml. An anonymous customer found positive results in IHC on Mouse pancreas. Western Blot: Preliminary experiments gave an approx 35-38kDa band in human pancreas lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 10.5kDa according to NP_002713.1. The 38kDa band was successfully blocked by incubation with the immunizing peptide.

other info1 :

Immunogen: Peptide with sequence C-TRPRYGKRHKEDT, from the internal region of the protein sequence according to NP_002713.1. Epitope: Internal region

ncbi gi num :

4506033

ncbi acc num :

NP_002713.1

ncbi gb acc num :

NM_002722.4

ncbi mol weight :

18,786 Da

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (i) Signalling Events Pathway (1269576); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); Peptide Ligand-binding Receptors Pathway (1269546); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543)

ncbi summary :

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

uniprot summary :

PPY: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Belongs to the NPY family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 17q21. Cellular Component: cytoplasm; extracellular region; extracellular space. Molecular Function: G-protein-coupled receptor binding; hormone activity; neuropeptide hormone activity; receptor binding. Biological Process: cell-cell signaling; digestion; feeding behavior; neuropeptide signaling pathway; positive regulation of defense response to virus by host; protein secretion; regulation of appetite

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage