antibody

Goat anti-ACHE Antibody

MBS420039

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, cow

western blot, enzyme immunoassay

Antibody

Goat anti-ACHE Antibody

ACHE

ACHE; YT; acetylcholinesterase (YT blood group); ARACHE; N-ACHE; OTTHUMP00000211347; OTTHUMP00000211349; OTTHUMP00000211356; acetylcholinesterase; apoptosis-related acetylcholinesterase; YT; acetylcholinesterase (YT blood group); ARACHE; N-ACHE; OTTHUMP00000211347; OTTHUMP00000211349; OTTHUMP00000211356; acetylcholinesterase; apoptosis-related acetylcholinesterase

acetylcholinesterase isoform E4-E6; Acetylcholinesterase; acetylcholinesterase; Yt blood group; apoptosis-related acetylcholinesterase; acetylcholinesterase (Yt blood group)

ACHE

ACHE; ACHE; YT; ACEE; ARACHE; N-ACHE; AChE

ACES_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Cow

614

QFDHYSKQDRCSDL

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 70kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 67.8kDa according to NP_000656.1). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:2000.

Epitope: C Terminus. Immunogen: Peptide with sequence QFDHYSKQDRCSDL, from the C Terminus of the protein sequence according to NP_000656.1. Corresponding Immunizing Peptide: Catalog #MBS425137

Important Note: This antibody is expected to recognise isoform NP_000656 only (the ubiquitously expressed, hydrophillic form).

4557239

NP_000656.1

NM_000665.4

58,352 Da

ATF-2 Transcription Factor Network Pathway 138006!!Acetylcholine Synthesis Pathway 198820!!Biogenic Amine Synthesis Pathway 198793!!Cholinergic Synapse Pathway 217716!!Glycerophospholipid Biosynthesis Pathway 645313!!Glycerophospholipid Metabolism Pathway 82989!!Glycerophospholipid Metabolism Pathway 364!!Integrated Pancreatic Cancer Pathway 711360!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD