Goat anti-TGM2 Antibody | MyBioSource MBS420035 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TGM2 Antibody

catalog :

MBS420035

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420035

products type :

Antibody

products full name :

Goat anti-TGM2 Antibody

products short name :

TGM2

products name syn :

Goat Anti-Transglutaminase 2 (aa578-591) Antibody; TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); TG2; TGC; C polypeptide; TGase C; TGase-H; protein-glutamine-gamma-glutamyltransferase; tissue transglutaminase; transglutaminase 2; transglutaminase C; TGM2 antibody; transglutaminase 2 (C polypeptide; protein-glutamine-gamma-glutamyltransferase) antibody; TG2 antibody; TGC antibody; C polypeptide antibody; TGase C antibody; TGase-H antibody; protein-glutamine-gamma-glutamyltransferase antibody; tissue transglutaminase antibody; transglutaminase 2 antibody; transglutaminase C antibody

other names :

protein-glutamine gamma-glutamyltransferase 2 isoform a; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine gamma-glutamyltransferase 2; transglutaminase 2; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2

products gene name :

TGM2

other gene names :

TGM2; TGM2; TGC; TG(C); TG(C); TGC; TGase C; TGase H; TGase-2

uniprot entry name :

TGM2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

687

sequence :

NFESDKLKAVKGFR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 90kDa band observed in Human Lung lysates and approx 85kDa in lysates of cell line A549 (calculated MW of 77.3kDa according to NP_004604.2). Recommended concentration: 0. 03-0.1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-NFESDKLKAVKGFR, from the internal region (near the C Terminus) of the protein sequence according to NP_004604.2. Epitope: Internal region (near the C Terminus)

other info2 :

Note: This antibody is expected to recognise isoform a (NP_004604.2) only.

ncbi gi num :

39777597

ncbi acc num :

NP_004604.2

ncbi gb acc num :

NM_004613.3

ncbi mol weight :

38,671 Da

ncbi pathways :

Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Thromboxane A2 Receptor Signaling Pathway (138060)

ncbi summary :

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Protein type: Transferase; EC 2.3.2.13. Chromosomal Location of Human Ortholog: 20q12. Cellular Component: cytosol; endoplasmic reticulum; focal adhesion; intrinsic to plasma membrane; mitochondrion. Molecular Function: metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity. Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peptide cross-linking; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage