Goat anti-Ogg1 (mouse) Antibody | MyBioSource MBS420013 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Ogg1 (mouse) Antibody

catalog :

MBS420013

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420013

products type :

Antibody

products full name :

Goat anti-Ogg1 (mouse) Antibody

products short name :

Ogg1

products name syn :

Ogg1; 8-oxoguanine DNA glycosylase; Mmh; Ogg1 antibody; 8-oxoguanine DNA glycosylase antibody; Mmh antibody; Ogg1 (mouse)

other names :

8-oxoguanine DNA-glycosylase 1; N-glycosylase/DNA lyase; N-glycosylase/DNA lyase; 8-oxoguanine DNA-glycosylase 1

products gene name :

OGG1

other gene names :

Ogg1; Ogg1; Mmh; AP lyase

uniprot entry name :

OGG1_MOUSE

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Rat; Expected from sequence similarity: Mouse, Rat

sequence length :

345

sequence :

HPKTSQAKGPSPLANK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Approx 37kDa band observed in Rat Spleen lysates (calculated MW of 38.7kDa according to Rat NP_110497.1 and 38.8kDa according to Mouse NP_035087.2). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-HPKTSQAKGPSPLANK, from the internal region of the protein sequence according to NP_035087.2. Epitope: Internal region

ncbi gi num :

18921208

ncbi acc num :

NP_035087.2

ncbi gb acc num :

NM_010957.3

ncbi mol weight :

38,883 Da

ncbi pathways :

APEX1-Independent Resolution Of AP Sites Via The Single Nucleotide Replacement Pathway (1366821); Base Excision Repair Pathway (1366811); Base Excision Repair Pathway (83240); Base Excision Repair Pathway (451); Base-Excision Repair, AP Site Formation Pathway (1366812); Cleavage Of The Damaged Purine Pathway (1366814); Cleavage Of The Damaged Pyrimidine Pathway (1366816); DNA Repair Pathway (1366810); Depurination Pathway (1366813); Depyrimidination Pathway (1366815)

uniprot summary :

OGG1: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Belongs to the type-1 OGG1 family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Deoxyribonuclease; Lyase; DNA repair, damage; EC 4.2.99.18. Cellular Component: mitochondrion; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex. Molecular Function: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; catalytic activity; damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-3-methyladenine glycosylase III activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; lyase activity; microtubule binding; oxidized base lesion DNA N-glycosylase activity; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; purine-specific mismatch base pair DNA N-glycosylase activity; single-strand selective uracil DNA N-glycosylase activity; uracil DNA N-glycosylase activity. Biological Process: aging; base-excision repair; DNA repair; metabolic process; negative regulation of apoptosis; nucleotide-excision repair; nucleotide-excision repair, DNA incision; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to estradiol stimulus; response to oxidative stress; response to radiation

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage