Goat anti-Dual oxidase 1 Antibody | MyBioSource MBS420008 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Dual oxidase 1 Antibody

catalog :

MBS420008

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420008

products type :

Antibody

products full name :

Goat anti-Dual oxidase 1 Antibody

products short name :

Dual oxidase 1

products name syn :

Goat Anti-DUOX1 (aa972-985) Antibody; DUOX1; dual oxidase 1; LNOX1; MGC138840; MGC138841; NOXEF1; THOX1; NADPH thyroid oxidase 1; flavoprotein NADPH oxidase; nicotinamide adenine dinucleotide phosphate oxidase; DUOX1 antibody; dual oxidase 1 antibody; LNOX1 antibody; MGC138840 antibody; MGC138841 antibody; NOXEF1 antibody; THOX1 antibody; NADPH thyroid oxidase 1 antibody; flavoprotein NADPH oxidase antibody; nicotinamide adenine dinucleotide phosphate oxidase antibody; Dual oxidase 1; Dual oxidase 1

other names :

dual oxidase 1; Dual oxidase 1; dual oxidase 1; dual oxidase 1; Large NOX 1; Long NOX 1; NADPH thyroid oxidase 1; Thyroid oxidase 1

products gene name :

DUOX1

other gene names :

DUOX1; DUOX1; LNOX1; THOX1; NOXEF1; DUOX; LNOX1; THOX1

uniprot entry name :

DUOX1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

1551

sequence :

EKFQRSCLHQTVQ

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Thyroid shows staining of membranes in epithelial cells of the gland. Recommended concentration, 4-6ug/ml. Western Blot: Preliminary experiments in Human Placenta and Thyroid Gland lysates gave no specific signal but low background (at antibody concentration up to 0.5ug/ml).

other info1 :

Immunogen: Peptide with sequence EKFQRSCLHQTVQ, from the internal region of the protein sequence according to NP_059130.2 ; NP_787954.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognise both reported isoforms (NP_059130.2 ; NP_787954.1) which are identical;

ncbi gi num :

20149640

ncbi acc num :

NP_059130.2

ncbi gb acc num :

NM_017434.4

ncbi mol weight :

137,604 Da

ncbi pathways :

Amine-derived Hormones Pathway (1270175); Metabolism Pathway (1269956); Metabolism Of Amino Acids And Derivatives Pathway (1270158); Thyroxine Biosynthesis Pathway (1270177)

ncbi summary :

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

DUOX1: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Oxidoreductase; EC 1.6.3.1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 15q15.3. Cellular Component: apical plasma membrane; integral to membrane; plasma membrane. Molecular Function: calcium ion binding; heme binding; NAD(P)H oxidase activity; NADP binding; peroxidase activity. Biological Process: cuticle development; cytokine and chemokine mediated signaling pathway; hormone biosynthetic process; hydrogen peroxide biosynthetic process; hydrogen peroxide catabolic process; response to cAMP; response to oxidative stress; superoxide release; thyroid hormone generation

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage