product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-LIG3 Antibody
catalog :
MBS419871
quantity :
0.1 mg
price :
385 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
image
image 1 :
image 2 :
product information
catalog number :
MBS419871
products type :
Antibody
products full name :
Anti-LIG3 Antibody
products short name :
[LIG3]
other names :
[LIG3 protein; DNA ligase 3; DNA ligase 3; DNA ligase 3; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3]
products gene name :
[LIG3]
other gene names :
[LIG3; LIG3; LIG2]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
299
specificity :
Western blot analysis of extracts of various cell lines, using LIG3 antibody (1:1000). Immunohistochemistry of paraffin-embedded human breast cancer using LIG3 antibody at dilution of 1:200 (400x lens). Immunohistochemistry of paraffin-embedded rat brain using LIG3 antibody at dilution of 1:200 (400x lens). Immunofluorescence analysis of MCF7 cell using LIG3 antibody. Blue: DAPI for nuclear staining.
purity :
Affinity Purification
form :
Liquid
concentration :
1mg/ml
storage stability :
Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50- 1:200. IF: 1:50- 1:200
image1 heading :
Western Blot (WB)
image2 heading :
Immunofluorescence (IF)
other info1 :
Immunogen: Recombinant protein of human LIG3. Antibody Type: Primary Antibody
other info2 :
Storage Buffer: PBS with 0.02% sodium azide,50% glycerol, pH7.3.
products description :
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ncbi gi num :
14290516
ncbi acc num :
AAH09026.1
ncbi pathways :
BER Complex Pathway (413429); BER Complex Pathway (468377); Base Excision Repair Pathway (105838); Base Excision Repair Pathway (83043); Base Excision Repair Pathway (451); DNA Repair Pathway (105837); Resolution Of AP Sites Via The Single-nucleotide Replacement Pathway (105847); Resolution Of Abasic Sites (AP Sites) Pathway (105846)
ncbi summary :
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
uniprot summary :
LIG3: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Belongs to the ATP-dependent DNA ligase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.5.1.1; Ligase. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: nucleoplasm; nucleus. Molecular Function: DNA ligase activity; protein binding. Biological Process: base-excision repair, DNA ligation; double-strand break repair; double-strand break repair via homologous recombination; lagging strand elongation; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair; V(D)J recombination
size1 :
0.1 mg
price1 :
385 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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