catalog number :
MBS418965
products full name :
Anti-VPS29 (Internal) Antibody
products short name :
[VPS29]
other names :
[vacuolar protein sorting-associated protein 29 isoform 2; Vacuolar protein sorting-associated protein 29; vacuolar protein sorting-associated protein 29; VPS29, retromer complex component; PEP11 homolog; Vesicle protein sorting 29]
products gene name :
[VPS29]
other gene names :
[VPS29; VPS29; DC7; DC15; PEP11; hVPS29]
reactivity :
Human, Mouse, Rat, Other
purity :
Affinity Purified
concentration :
100ug/200ul
storage stability :
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
tested application :
Western Blot (WB), ELISA (EIA)
other info1 :
Immunogen: CTGNLCTKESYDYLK
other info2 :
Storage Buffer: Supplied at 0.5 mg/ml in Tris saline,0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
products description :
Polyclonal Goat Antibody
ncbi acc num :
NP_476528.1
ncbi gb acc num :
NM_057180.2
ncbi pathways :
Disease Pathway (530764); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); WNT Ligand Biogenesis And Trafficking Pathway (833832); WNT Ligand Secretion Is Abrogated By The PORCN Inhibitor LGK974 Pathway (1127634); Serine And Glycine Biosynthesis Pathway (142128); Serine Biosynthesis (phosphorylated Route) Pathway (142173)
ncbi summary :
This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]
uniprot summary :
VPS29: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Belongs to the VPS29 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.3.3; Protein phosphatase, Ser/Thr (non-receptor); Vesicle. Chromosomal Location of Human Ortholog: 12q24.11. Cellular Component: cytoplasm; cytosol; endosome; intracellular membrane-bound organelle; retromer complex. Molecular Function: protein binding; protein transporter activity. Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway