antibody

Anti-ITPR3 Antibody

MBS418774

0.1 mg

385 USD

polyclonal

goat

nonconjugated

human, mouse, rat, cow

western blot, ELISA, enzyme immunoassay

Antibody

Anti-ITPR3 Antibody

[ITPR3]

[ITPR3 protein, partial; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor]

[ITPR3]

[ITPR3; ITPR3; IP3R; IP3R3; IP3R 3; InsP3R3; Type 3 InsP3 receptor]

Polyclonal

IgG

Goat

Human, Mouse, Rat, Bovine, Other

1049

Affinity Purified

Liquid

100ug/200ul

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB), ELISA (EIA)

Antibody Type: Primary antibody. Immunogen: DKKERPTDEEGFLH

Storage Buffer: Supplied at 0.5 mg/ml in Tris saline,0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin

Polyclonal Goat Antibody

148921515

AAI46647.1

Adaptive Immune System Pathway (366160); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Ca2+ Pathway (1127532); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cholinergic Synapse Pathway (217716)

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family. Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 6p21.31. Cellular Component: apical part of cell; brush border; cell soma; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; myelin sheath; nuclear outer membrane; plasma membrane; receptor complex; sarcoplasmic reticulum; secretory granule membrane. Molecular Function: calcium ion binding; calcium-release channel activity; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; phosphoinositide binding; protein binding. Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; platelet activation; protein heterooligomerization; protein homooligomerization; regulation of insulin secretion; response to calcium ion. Disease: Diabetes Mellitus, Insulin-dependent

0.1 mg

385 USD