antibody

Anti-EZRIN Antibody

MBS417348

0.1 mg

405 USD

polyclonal

rabbit

nonconjugated

human, mouse

Antibody

Anti-EZRIN Antibody

[EZRIN]

[ezrin; Ezrin; ezrin; cytovillin 2; epididymis secretory protein Li 105; p81; villin 2 (ezrin); villin-2; ezrin; Cytovillin; Villin-2; p81]

[EZRIN]

[EZR; EZR; CVL; CVIL; VIL2; HEL-S-105]

EZRI_HUMAN

Polyclonal

Rabbit

Human, Mouse

586

Ezrin (Ab-353) antibody detects endogenous levels of total Ezrin protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Liquid

1ug/ul

This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

WB: 1:500~1:1000

Western Blot (WB)

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Ezrin around the phosphorylation site of tyrosine 353 (Q-D-YP-E-E).

Zhao H, et al. (2004) Proc Natl Acad Sci U S A101 (25): 9485-90. Wang Q, et al. (2003) J Biol Chem 278(48): 47731-43. Gautreau A, et al. (1999) Proc Natl Acad Sci U S A: 96(13): 7300-5. Crepaldi T, et al. (1997) J Cell Biol: 28; 138(2): 423-34.

21614499

NP_003370.2

NM_003379.4

AGE/RAGE Pathway (698754); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); FAS (CD95) Signaling Pathway (138081); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); L1CAM Interactions Pathway (161003); LKB1 Signaling Events Pathway (137957); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494)

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]

Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 6q25.3. Cellular Component: cortical cytoskeleton; extracellular space; focal adhesion; microvillus; basolateral plasma membrane; T-tubule; actin filament; cytosol; lipid raft; actin cytoskeleton; ruffle; extrinsic to membrane; membrane; microvillus membrane; apical part of cell; apical plasma membrane; plasma membrane; nucleolus; uropod; vesicle; filopodium. Molecular Function: actin filament binding; protein domain specific binding; protein binding; cell adhesion molecule binding. Biological Process: actin filament bundle formation; regulation of cell shape; microvillus biogenesis; axon guidance; leukocyte adhesion; filopodium formation; cytoskeletal anchoring; receptor internalization; membrane to membrane docking; establishment of epithelial cell polarity

0.1 mg

405 USD