antibody

Anti-TGFB2 Antibody

MBS416658

0.1 mL

230 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat, zebrafish

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Anti-TGFB2 Antibody

[TGFB2]

[transforming growth factor beta-2; transforming growth factor beta-2; tgf beta 2; transforming growth factor, beta 2]

[TGFB2]

[tgfb2]

Polyclonal

IgG

Rabbit

Human, Mouse, Rat. Not yet tested in other species.

411

Affinity purified

Liquid

This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

ELISA (EIA), Immunohistochemistry (IHC)

Peptide ELISA titer: 1:1,000-1:10,000. Immunohistochemistry: 1:100-500. Optimal dilutions/concentrations should be determined by the end user

Immunohistochemistry (IHC)

Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen: Rabbit polyclonal TGFB2 antibody was raised against a peptide from N terminal residues of human TGFB2 protein.

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

(1) Schierano,G., Pejrone,G., Brusco,P., et al.TNF-alpha TGF-beta2 and IL-1beta levels in gingival and peri-implant crevicular fluid before and after de novo plaque accumulation. J. Clin. Periodontol. 35 (6), 532-538 (2008)

35902884

NP_919366.1

NM_194385.1

Cell Cycle Pathway (83631); Cell Cycle Pathway (463); Cytokine-cytokine Receptor Interaction Pathway (119260); Cytokine-cytokine Receptor Interaction Pathway (460); ECM Proteoglycans Pathway (1114001); ERK1 - ERK2 MAPK Cascade Pathway (198962); Elastic Fibre Formation Pathway (1113996); Endochondral Ossification Pathway (921002); Endocytosis Pathway (102262); Endocytosis Pathway (102181)

0.1 mL

230 USD