antibody

Anti-DUSP26 Antibody

MBS416574

0.1 mg

230 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Anti-DUSP26 Antibody

[DUSP26]

[dual specificity protein phosphatase 26; Dual specificity protein phosphatase 26; dual specificity protein phosphatase 26; MAP kinase phosphatase 8; Novel amplified gene in thyroid anaplastic cancer; dual specificity phosphatase SKRP3; low-molecular-mass dual-specificity phosphatase 4; mitogen-activated protein kinase phosphatase 8; neuroendocrine-associated phosphatase; dual specificity phosphatase 26 (putative); Dual specificity phosphatase SKRP3; Low-molecular-mass dual-specificity phosphatase 4; DSP-4; LDP-4; Mitogen-activated protein kinase phosphatase 8; MAP kinase phosphatase 8; MKP-8; Novel amplified gene in thyroid anaplastic cancer]

[DUSP26]

[DUSP26; DUSP26; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24]

DUS26_HUMAN

Polyclonal

Rabbit

Human. Predicted: Mouse, Rat.

211

Human and predicted against mouse and rat.

Affinity purified

Liquid

100ug/100ul

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:1,000-1:2,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.

Testing Data

Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide. Antibody Type: Primary Antibody

Immunogen: Rabbit polyclonal DUSP26 (1) antibody was raised against a recombinate human DUSP26 protein 2 -211aa (BC001613).

(1) Shang,X., Vasudevan,S.A., Yu,Y. et al. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene 29 (35), 4938-4946 (2010).

13128968

NP_076930.1

NM_024025.2

9,652 Da

This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16. Chromosomal Location of Human Ortholog: 8p12. Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleus. Molecular Function: protein binding; phosphoserine phosphatase activity; p53 binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity. Biological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation

0.1 mg

230 USD