Anti-FXR Antibody | MyBioSource MBS416423 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-FXR Antibody

catalog :

MBS416423

quantity :

0.1 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS416423

products type :

Antibody

products full name :

Anti-FXR Antibody

products short name :

[FXR]

other names :

[Homo sapiens nuclear receptor subfamily 1, group H, member 4 (NR1H4), transcript variant 2, mRNA; Bile acid receptor; bile acid receptor; RXR-interacting protein 14; farnesoid X nuclear receptor; farnesoid X-activated receptor; farnesol receptor HRR-1; retinoid X receptor-interacting protein 14; nuclear receptor subfamily 1, group H, member 4; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14]

products gene name :

[FXR]

other gene names :

[NR1H4; NR1H4; BAR; FXR; HRR1; HRR-1; RIP14]

uniprot entry name :

NR1H4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

2313

specificity :

Not yet tested in other species.

purity :

Affinity purified

form :

Liquid

concentration :

100ug/100ul

storage stability :

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA titer: 1:1,000-1:5,000. Western blot analysis: 1:200-500. Optimal dilutions/concentrations should be determined by the end user.

image1 heading :

Western Blot (WB)

other info1 :

Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide

other info2 :

Immunogen: Synthetic peptide conjugated to KLH

products references :

(1) Papetti,M., Wood,N., Lohmar,P.D.et al. Direct Submission.Submitted (28-AUG-1996) Immunology and Hematopoiesis, Genetics Institute, 87 CambridgePark Drive, Cambridge, MA 02140, USA

ncbi gi num :

332801020

ncbi acc num :

NP_005114.1

ncbi gb acc num :

NM_005123

ncbi mol weight :

48,795 Da

ncbi pathways :

Bile Acid And Bile Salt Metabolism Pathway (106144); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Biological Oxidations Pathway (105698); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway (1127640); Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway (1127641); Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway (1127642); Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway (1127643); Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway (1127644)

ncbi summary :

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

uniprot summary :

NR1H4: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. Heterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2. Interacts with CARM1 and SMARD1. Belongs to the nuclear hormone receptor family. NR1 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 12q23.1. Cellular Component: nucleoplasm. Molecular Function: ligand-dependent nuclear receptor binding; RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; zinc ion binding; bile acid binding; transcription coactivator activity; peptide binding; retinoid X receptor binding; protein binding; sequence-specific DNA binding; double-stranded DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription corepressor activity; transcription factor activity. Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; gut development; bile acid metabolic process; response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; response to lipopolysaccharide; gene expression; regulation of carbohydrate metabolic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction

size1 :

0.1 mL

price1 :

230 USD

more info or order :

MyBioSource product webpage