antibody

Anti-TNKS2 Antibody

MBS416286

0.1 mg

230 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Anti-TNKS2 Antibody

[TNKS2]

[tankyrase-2; Tankyrase-2; tankyrase-2; ADP-ribosyltransferase diphtheria toxin-like 6; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; poly [ADP-ribose] polymerase 5B; tankyrase 2; tankyrase II; tankyrase-like protein; tankyrase-related protein; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-like protein; Tankyrase-related protein]

[TNKS2]

[TNKS2; TNKS2; TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c]

TNKS2_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat.

1166

Affinity purified

Liquid;PBS, pH 7.4 with 0.02% Sodium Azide

This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

ELISA (EIA), Western Blot, Immunohistochemistry (IHC)

Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.

Immunohistochemistry (IHC)

(1) Casabonne,D., Reina,O., Benavente,Y., et al. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Haematologica 96 (2), 323-327 (2011)

13376842

NP_079511.1

NM_025235.3

126,918 Da

Disease Pathway (530764); RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway (1127632); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516); XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway (1127633); Degradation Of AXIN Pathway (1127523); Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway (1127631)

TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Protein type: Nuclear envelope; EC 2.4.2.30; Transferase. Chromosomal Location of Human Ortholog: 10q23.3. Cellular Component: Golgi membrane; pericentriolar material; nuclear chromosome, telomeric region; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; nucleus; cytosol. Molecular Function: protein binding; enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity. Biological Process: protein amino acid ADP-ribosylation; protein polyubiquitination; Wnt receptor signaling pathway; multicellular organism growth; regulation of multicellular organism growth; positive regulation of telomere maintenance via telomerase

0.1 mg

230 USD