product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-ORC5L Antibody
catalog :
MBS416145
quantity :
0.1 mg
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
product information
catalog number :
MBS416145
products type :
Antibody
products full name :
Anti-ORC5L Antibody
products short name :
[ORC5L]
other names :
[origin recognition complex subunit 5 isoform 2; Origin recognition complex subunit 5; origin recognition complex subunit 5; protein phosphatase 1, regulatory subunit 117; origin recognition complex, subunit 5]
products gene name :
[ORC5L]
other gene names :
[ORC5; ORC5; ORC5L; ORC5P; ORC5T; PPP1R117]
uniprot entry name :
ORC5_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, mouse, rat
sequence length :
324
specificity :
Human and predicted against mouse and rat.
purity :
Affinity purified
form :
Liquid
storage stability :
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
image1 heading :
Testing Data
other info1 :
Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
other info2 :
Immunogen: Rabbit polyclonal ORC5L (1) antibody was raised against a recombinate human ORC5L protein 65-354aa (BC023652).
products references :
(1) Siddiqui,K. and Stillman,B. ATP-dependent assembly of the human origin recognition complex. J. Biol. Chem. 282 (44), 32370-32383 (2007).
ncbi gi num :
32454754
ncbi acc num :
NP_859531.1
ncbi gb acc num :
NM_181747.3
ncbi pathways :
Activation Of ATR In Response To Replication Stress Pathway (105754); Activation Of The Pre-replicative Complex Pathway (105777); Assembly Of The ORC Complex At The Origin Of Replication Pathway (105822); Assembly Of The Pre-replicative Complex Pathway (105821); Association Of Licensing Factors With The Pre-replicative Complex Pathway (105900); CDC6 Association With The ORC:origin Complex Pathway (105823); CDT1 Association With The CDC6:ORC:origin Complex Pathway (105824); Cell Cycle Pathway (530733); Cell Cycle Checkpoints Pathway (105739); Cell Cycle, Mitotic Pathway (105765)
ncbi summary :
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
uniprot summary :
ORC5L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC5 family. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 7q22.1. Cellular Component: nucleoplasm; cytoplasm; nucleus; nuclear origin of replication recognition complex; origin recognition complex. Molecular Function: protein binding; nucleotide binding; DNA replication origin binding; ATP binding. Biological Process: DNA replication initiation; mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
size1 :
0.1 mg
price1 :
230 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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