catalog number :
MBS416063
products full name :
Anti-APLP2 Antibody
products short name :
APLP2
products gene name :
APLP2
reactivity :
Human, mouse, rat
specificity :
Human and predicted against mouse and rat
purity :
Affinity purified
concentration :
100ug/100ul
storage stability :
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:1,000-1:2,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
other info2 :
Immunogen: Rabbit polyclonal APLP2 (1) antibody was raised against a recombinate human APLP2 protein 262-491aa (BC000373).
products description :
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
products references :
(1) Peters,H.L., Tuli,A., Sharma,M. et al. Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. Immunol. Res. 51 (1), 39-44 (2011).