product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-IYD Antibody
catalog :
MBS415548
quantity :
0.1 mg
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
image
image 1 :
image 2 :
product information
catalog number :
MBS415548
products type :
Antibody
products full name :
Anti-IYD Antibody
products short name :
[IYD]
other names :
[Homo sapiens iodotyrosine deiodinase, mRNA; Iodotyrosine dehalogenase 1; iodotyrosine dehalogenase 1; IYD-1; iodotyrosine deiodinase]
products gene name :
[IYD]
other gene names :
[IYD; IYD; TDH4; DEHAL1; C6orf71; dJ422F24.1]
uniprot entry name :
IYD1_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human
sequence length :
1260
purity :
Affinity purified
form :
Liquid
concentration :
100ug/100ul
storage stability :
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:1,000-1:2,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC) #2 (IHC)
other info1 :
Antibody Type: Primary antibody. Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
other info2 :
Immunogen: Raised against a recombinate human IYD protein 54-203aa (BC056253).
products description :
Rabbit polyclonal IYD
products references :
(1) Moreno,J.C. and Visser,T.J. Genetics and phenomics of hypothyroidism and goiter due to iodotyrosine deiodinase (DEHAL1) gene mutations. Mol. Cell. Endocrinol. 322 (1-2), 91-98 (2010).
ncbi gi num :
33989988
ncbi acc num :
BC056253
ncbi mol weight :
22,460 Da
ncbi pathways :
Amine-derived Hormones Pathway (160983); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541); Thyroxine Biosynthesis Pathway (160985)
ncbi summary :
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
uniprot summary :
IYD: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. Defects in IYD are the cause of thyroid dyshormonogenesis 4 (TDH4). A disorder due to thyroid dyshormonogenesis, causing severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized and untreated hypothyroidism. Belongs to the nitroreductase family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 1.22.1.1; Oxidoreductase. Chromosomal Location of Human Ortholog: 6q25.1. Cellular Component: integral to membrane; plasma membrane. Molecular Function: iodide peroxidase activity; oxidoreductase activity. Biological Process: thyroid hormone generation. Disease: Thyroid Dyshormonogenesis 4
size1 :
0.1 mg
price1 :
230 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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