Anti-human TACSTD2/TROP-2 Monoclonal Antibody | MyBioSource MBS415353 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-human TACSTD2/TROP-2 Monoclonal Antibody

catalog :

MBS415353

quantity :

0.1 mg

price :

305 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS415353

products type :

Antibody

products full name :

Anti-human TACSTD2/TROP-2 Monoclonal Antibody

products short name :

[TACSTD2/TROP-2]

products name syn :

[Anti-human TACSTD2/TROP-2 Monoclonal]

other names :

[Homo sapiens tumor-associated calcium signal transducer 2 (TACSTD2), mRNA; Tumor-associated calcium signal transducer 2; tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733; tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1]

products gene name :

[TACSTD2/TROP-2]

other gene names :

[TACSTD2; TACSTD2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; GA733-1; M1S1; TROP2]

uniprot entry name :

TACD2_HUMAN

clonality :

Monoclonal

isotype :

IgG1 (Igh-4a allotype)

host :

Mouse

reactivity :

Human

sequence length :

2080

specificity :

The antibody defines TROP-2 that is expressed on trophoblasts and choriocarcinoma cells but not on blood cells or other tumor cells.

purity :

Affinity purified

form :

Liquid

concentration :

100ug/100ul

storage stability :

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

tested application :

Immunofluorescence (IF), Immunocytochemistry (ICC)

app notes :

Immunostaining, immunofluorescence: optimal dilutions to be determined by researchers.

image1 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Human choriocarcinoma cell line BeWo. Antibody Type: Primary Antibody

other info2 :

Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.

products description :

Tumor-associated calcium signal transducer 2, a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clone #: 162-46.2

products references :

Lipinski M, et al. Human trophoblast cell-surface antigens defined by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 78: 5147-5150, 1981.

ncbi gi num :

166795235

ncbi acc num :

NP_002344.2

ncbi gb acc num :

NM_002353.2

uniprot acc num :

P09758

ncbi mol weight :

35,709 Da

ncbi summary :

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

uniprot summary :

Function: May function as a growth factor receptor. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Placenta, pancreatic carcinoma cell lines. Post-translational modification: The N-terminus is blocked. Involvement in disease: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8. Sequence similarities: Belongs to the EPCAM family.Contains 1 thyroglobulin type-1 domain.

size1 :

0.1 mg

price1 :

305 USD

more info or order :

MyBioSource product webpage