Anti-GOT2 Antibody | MyBioSource MBS415259 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-GOT2 Antibody

catalog :

MBS415259

quantity :

0.1 mL

price :

445 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS415259

products type :

Antibody

products full name :

Anti-GOT2 Antibody

products short name :

GOT2

other names :

Homo sapiens glutamic-oxaloacetic transaminase 2, mitochondrial (GOT2), mRNA; Aspartate aminotransferase, mitochondrial; aspartate aminotransferase, mitochondrial; FABP-1; FABPpm; aspartate aminotransferase 2; aspartate transaminase 2; fatty acid-binding protein; glutamate oxaloacetate transaminase 2; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAspAT; plasma membrane-associated fatty acid-binding protein; transaminase A; glutamic-oxaloacetic transaminase 2, mitochondrial; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A

products gene name :

GOT2

other gene names :

GOT2; GOT2; KAT4; KATIV; mitAAT

uniprot entry name :

AATM_HUMAN

clonality :

Monoclonal

isotype :

IgG1

host :

Mouse

sequence length :

2473

specificity :

Anti-GOT2 recognizes GOT2 expression in HepG2 whole cell lysate.

purity :

Affinity purified

form :

Liquid

concentration :

100ug/100ul

storage stability :

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

tested application :

ELISA (EIA), Western Blot (WB-Re), Western Blot (WB-Ce)

app notes :

WB: 1:1000 analysis of GOT2 expression in HepG2 whole cell lysate with Anti-GOT2

other info1 :

Raised In: Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein GOT2 as immunogen. Storage Buffer: citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

other info2 :

Immunogen: Recombinant protein corresponding to fragment (aa/25-430) GOT2.

ncbi gi num :

73486657

ncbi acc num :

NP_002071.2

ncbi gb acc num :

NM_002080.2

ncbi mol weight :

43,030 Da

ncbi pathways :

2-Oxocarboxylic Acid Metabolism Pathway (714485); 2-Oxocarboxylic Acid Metabolism Pathway (717400); 4-hydroxyproline Degradation Pathway (142337); Alanine And Aspartate Metabolism Pathway (198783); Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Biosynthesis Of Amino Acids Pathway (790012)

ncbi summary :

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

uniprot summary :

GOT2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 2.6.1.1; Amino Acid Metabolism - cysteine and methionine; EC 2.6.1.7; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Mitochondrial; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Transferase. Chromosomal Location of Human Ortholog: 16q21. Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane; plasma membrane. Molecular Function: kynurenine-oxoglutarate transaminase activity; aspartate transaminase activity; pyridoxal phosphate binding. Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; aspartate biosynthetic process; glucose metabolic process; pathogenesis; 2-oxoglutarate metabolic process; gluconeogenesis; response to ethanol; 4-hydroxyproline catabolic process; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; fatty acid transport

size1 :

0.1 mL

price1 :

445 USD

more info or order :

MyBioSource product webpage