antibody

Anti-TFEB Antibody

MBS415007

0.1 mg

400 USD

monoclonal

mouse

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Anti-TFEB Antibody

[TFEB]

[Homo sapiens transcription factor EB (TFEB), transcript variant 1, mRNA; Transcription factor EB; transcription factor EB; T-cell transcription factor EB; class E basic helix-loop-helix protein 35; transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35]

[TFEB]

[TFEB; TFEB; TCFEB; BHLHE35; ALPHATFEB]

TFEB_HUMAN

Monoclonal

IgG1

Mouse

Human

2364

Anti-TFEB recognizes TFEB expression in Hela whole cell lysate

Affinity purified

Liquid

100ug/100ul

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

ELISA (EIA), Western Blot (WB)

WB: 1:1000 analysis of TFEB expression in Hela whole cell lysate with Anti-TFEB

Testing Data

Raised In: Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein TFEB as immunogen. Buffer: citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300. Antibody Type: Primary antibody.

Immunogen: Recombinant protein corresponding to full length TFEB.

268607698

NP_009093.1

NM_007162

43,803 Da

TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3 -CANNTG-5 ). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5 -GTCACGTGAC-3 ) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytoplasm; nucleus. Molecular Function: protein dimerization activity; transcription factor activity. Biological Process: embryonic placenta development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; lysosome organization and biogenesis; autophagy; positive regulation of transcription from RNA polymerase II promoter; humoral immune response; positive regulation of autophagy

0.1 mg

400 USD