catalog number :
MBS405734
products type :
Active Peptide
products full name :
Hepcidin / LEAP-1
products short name :
[Hepcidin / LEAP-1]
storage stability :
Storage(solution): After preparing 100-200 ul aliquots, freeze them at -20°C or below until use. The aqueous solution should be used within a few weeks. Storage (powder): The undissolved compound should be stored below -20°C.
other info1 :
Solution: Do not remove the cap. Inject 390 ,.11 of distilled water into the vial using a calibrated syringe. Dissolve all the contents thoroughly. This procedure furnishes a 0.1 mM solution of the titled compound.
other info2 :
Structure: Asp-Thr-His-Phe-Pro-lle-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-ArgSer-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr. (Reported disulfide bonds between Cys 7 -Cys 23 , Cys10-CYS 13 , Cys 11 -Cys 19 , and Cys 14 -Cys 22 ). Molecular Structure: C 113 H 170 N 34 O 31 S 9
products categories :
Biologically Active Peptide
products description :
Hepcidin / LEAP-1 (Human) Liver-Expressed Antimicrobial Peptide 1 (Human) Hepcidin-25 Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bonds between Cys7- Cys23, Cys10-Cys13, Cys11- Cys19, and Cys14-Cys22 [reference 5 below]) (M.W. 2789.4) C113H170N34O31S9 Liver-Specific Antimicrobial Peptide / Iron-Regulatory Hormone (Regulation of Iron Homeostasis) 1. A. Krause, S. Neitz, H.-J. Mägert, A. Schulz, W.-G. Forssmann, P. Schulz-Knappe, and K. Adermann,FEBS Lett.,480,147 (2000).(Original; LEAP-1) 2. C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz,J. Biol. Chem.,276,7806 (2001).(Original; Hepcidin) 3. T. Ganz and E. Nemeth, Am. J. Physiol., 290, G199 (2006). (Review) 4. H.N. Hunter, D.B. Fulton, T. Ganz, and H.J. Vogel, J. Bio Chem., 277, 37597 (2007). (Previously Published S-S Bond Connectivity) 5. J. B. Jordan, L. Poppe, M. Haniu, T. Arvedson, R. Syed, V. Li, H. Kohno, H. Kim, P. D. Schnier, T. S. Harvey, L. P. Miranda, J. Cheetham, and B. J. Sasu,J. Biol. Chem., 284, 24155 (2009).(Hepcidin S-S Bond)