catalog number :
MBS405577
products type :
Biologically Active Peptide
products full name :
PLTX-II
products short name :
PLTX-II
sequence :
Ala-Asp-Cys-Ser-Ala-Thr-Gly-Asp-Thr-CysAsp- His-Thr-Lys-Lys-cys-cys-Asp-Asp-CysTyr- Thr-cys-Arg-Cys-Gly-Thr-Pro-Trp-GlyAla- Asn-Cys-Arg-Cys-Asp-Tyr-Tyr-Lys-AlaArg- Cys-Asp-Thr(Palmitoyl)-NHc. (Disulfide bonds undetermined). (M.W.5108.73) C203H313N61O70S10
form :
This vial contains exactly 0.10 mg (20 nmol ) of the titled compound, which has been lyophilized as an amorphous powder from aqueous solution. Apprearance: White amorphous powder
storage stability :
Storage (Solution): After preparing 100-200 ul aliquots, freeze them at -20 degree C or below until use. TIle aqueous solution should be used within a few weeks. Storage (powder): TIle undissolved peptide is stable at -2C degree C for more than one year.
other info1 :
Solution: Do not remove the cap. Inject 200 ul of 0.1% acetic acid solution into the vial using a calibrated syringe. Dissolve all the contents thoroughly. This procedure furnishes a 0.1 mM solution of the titled compound. Specific Optical Rotation: [Alpha]^20 D -5.5 * (c 0.26, H2O)
other info2 :
Amino Acid Analysis: Acid Hydolysis: 6N HCl. 110 degree C, 22h *with thioglycolic acid. Asp (8) 8.04 Thr (6) 5.73 Ser (1) 0.95 Pro (1) 1.03. Gly (3) 3.00 Ala (4) 3.90 1/2 Cystine (10) 9.66 Tyr (3)2.98. His (1)0.99 Lys (3)3.00 NH3 (2) 3.18 Trp(100.62*. Arg (3) 2.96. Thin Layer Chromatography: Single spot. Cellulose Layer: Application: 50ug. Solvent system: n-BuOH:AcOH:H2O:pyridine=15:3:12:10. Located by ninhydrin and Pauly reagent
products categories :
Biologically Active Peptide
products description :
(Spider, Plectreurys tristes) Ala-Asp-Cys-Ser-Ala-Thr-Gly-Asp-Thr-Cys-Asp-His-Thr-Lys-Lys-Cys-Cys-Asp-Asp-Cys-Tyr-Thr-Cys-Arg-Cys-Gly-Thr-Pro-Trp-Gly-Ala-Asn-Cys-Arg-Cys-Asp-Tyr-Tyr-Lys-Ala-Arg-Cys-Asp-Thr(Palmitoyl)-NH2 (Disulfide bonds undetermined) (M.W. 5108.7) C208H313N61O70S10 Presynaptic Ca2+ Channel Blocker W.D. Branton, L. Kolton, Y.N. Jan, and L.Y. Jan, J. Neurosci., 7, 4195 (1987). (Original) H.-T. Leung, W.D. Branton, H.S. Phillips, L. Jan, and L. Byerly, Neuron, 3, 767 (1989). (Pharmacol.) W.D. Branton, M.S. Rudnick, Y. Zhou, E.D. Eccleston, G.B. Fields, and L.D. Bowers, Nature, 365, 496 (1993). (Thr(Pal)amide) J. Bódi, H. Nishio, Y. Zhou, W.D. Branton, T. Kimura, and S. Sakakibara, Pept. Res., 8, 228 (1995). (Chem. Synthesis & Biological Activity)
ncbi mol weight :
5108.73