product summary
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company name :
MyBioSource
product type :
protein
product name :
Mouse interleukin 22 - pegylated
catalog :
MBS400082
quantity :
0.01 mg
price :
290 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS400082
products type :
Recombinant Protein
products full name :
Mouse interleukin 22 - pegylated
products short name :
interleukin 22
products name syn :
Mouse pegylated interleukin 22
other names :
interleukin-22; Interleukin-22; interleukin-22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; cytokine Zcyto18; interleukin 22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF
other gene names :
IL22; IL22; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23; ILTIF; ZCYTO18; IL-22; IL-TIF
uniprot entry name :
IL22_HUMAN
host :
E Coli
sequence length :
179
sequence :
The sequence of the N-terminal amino acids could not be determined indicating that the PEG moiety is attached to the N-terminus.
purity :
Greater than 98.0% as determined by:. (a) Gel filtration analysis. (b) Analysis by reducing and non-reducing SDS-PAGE gel.
form :
White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized pegylated mouse IL22 although stable at room temperature for several days, should be stored desiccated below -20 degree C. Upon reconstitution at > 0.1 pegylated mIL22 mg/ml and up to 2 mg/ml and filter sterilization it can be stored at 4 degree C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. At lower concentration addition of a carrier protein (0.1% HSA or BSA) is suggested. Please prevent freeze-thaw cycles.
other info1 :
Solubility: It is recommended to reconstitute the lyophilized pegylated mouse IL22 in sterile water or sterile 0.4% NaHCO3 adjusted to pH 8-9, not less than 100ug/ml, which can then be further diluted with other aqueous solutions. Protein Content: Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.26 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the DNAman computer analysis program of protein sequences. Dimers and Aggregates: The purified mouse pegylated IL22 consists of > 90% monomers as determined by gel-filtration chromatography.
other info2 :
Endotoxin: Less than 0.05 ng/ug (0.5 EU/ug) of recombinant pegylated IL-22. Formulation: The protein was lyophilized from a concentrated (0.65mg/ml) solution with 0.003mM NaHCO3. Biological Activity: murine IL-22 is biologically active when compared to standard using STAT3 phosphorylation assay in HepG cells. Its acrtivity in vitro is ~ 10% compared to the non-pegylated mIL22.
products categories :
Hormones, Cytokines and Growth Factors
products description :
Mono-pegylated (with 20 kDa PEG)recombinant mouse interleukin 22 is one polypeptide chain containing 147 amino, an additional Ala at N-terminus and one molecule of PEG 20 kDa at its N-terminus, having an expected molecular mass of ~ 36 kDa as determined by MS. However due to enlarged hydrodymanic volume it runs on the SGS-Page as 50 kDa protein and in gel-filtration on Superdex 200 as over 200 kDa protein. For more details see L. Niv-Spector et al. Protein Eng Des Sel. (PEDS) 25:397-404 (2012).
ncbi gi num :
10092625
ncbi acc num :
NP_065386.1
ncbi gb acc num :
NM_020525.4
uniprot acc num :
Q9GZX6
ncbi mol weight :
20,011 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)
uniprot summary :
IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family. Protein type: Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q15. Cellular Component: extracellular space; extracellular region. Molecular Function: cytokine activity; interleukin-22 receptor binding. Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response
size1 :
0.01 mg
price1 :
290 USD
size2 :
0.05 mg
price2 :
965
size3 :
0.1 mg
price3 :
1410
size4 :
1 mg
price4 :
5365
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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