antibody

a1C Calcium Channel

MBS395969

10 Miniblots

440 USD

polyclonal

rabbit

nonconjugated

Antibody

a1C Calcium Channel

a1C Calcium Channel

RBC-II; Cav1.2; Calcium channel (L type) voltage gated 1c; Cacna1c

voltage-dependent L-type calcium channel subunit alpha-1C isoform 18; Voltage-dependent L-type calcium channel subunit alpha-1C; voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*; calcium channel, voltage-dependent, L type, alpha 1C subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2

CACNA1C; CACNA1C; TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1; CACH2; CACN2; CACNL1A1; CCHL1A1

CAC1C_HUMAN

Polyclonal

IgG

Rabbit

Human

2138

Antigen Immunoaffiinity Purification

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Western Blot (WB)

Immunogen: Synthetic peptide derived from the rat alpha1C calcium channel conjugated to KLH

Positive Control: Normal human kidney tissue

Antigen Immunoaffinity Purified Polyclonal; Ion Channels

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1c gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart.

120433602

NP_000710.5

NM_000719.6

Q13936

248,977 Da

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Calcium Regulation In The Cardiac Cell Pathway (198906)

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. Ref.2 Ref.4 Ref.6 Ref.7 Ref.8 Ref.9. Subunit structure: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interacts with CACNA2D4. Interacts (via the N-terminus and the C-terminal C and IQ motifs) with CABP1. The binding via the C motif is calcium independent whereas the binding via IQ requires the presence of calcium and is mutually exclusive with calmodulin binding. The binding to the cytoplasmic N-terminal domain is calcium independent but is essential for the channel modulation. Interacts (via C-terminal CDB motif) with CABP5; in a calcium-dependent manner . By similarity. Ref.18 Ref.19 Ref.20. Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane . By similarity. Note: The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane . By similarity. Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. Ref.2 Ref.8 Ref.9. Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel . By similarity. Post-translational modification: Phosphorylation by PKA activates the channel . By similarity. Involvement in disease: Timothy syndrome (TS) [MIM:601005]: Disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.22 Ref.23Brugada syndrome 3 (BRGDA3) [MIM:611875]: A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.24. Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. [View classification]. Sequence caution: The sequence AAA02500.2 differs from that shown. Reason: Frameshift at position 1844.

10 Miniblots

440 USD